Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Dose dependent effect of benzene extract of Ocimum sanctum leaves on cauda epididymal spermatozoa of albino rats

  • Ahmed, Mukhtar (Department of Post-Graduate Studies and Research in Zoology, Karnatak University) ;
  • Ahamed, R. Nazeer (Department of Post-Graduate Studies and Research in Zoology, Karnatak University) ;
  • Aladakatti, R.H. (Department of Post-Graduate Studies and Research in Zoology, Karnatak University) ;
  • Ghodesawar, M.G. (Department of Post-Graduate Studies and Research in Zoology, Karnatak University)
  • Published : 2009.12.31
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Abstract

An attempt has been made to assess whether the dose dependent effect of benzene extract of Ocimum sanctum leaves on the morphological changes in the cauda epididymal spermatozoa and sperm parameters in male albino rats. Scanning Electron Microscope observations illustrate the disturbance in plasma membrane as well as acrosomal membrane. Most of the sperms appear morphologically abnormal in the mid region of the tail; there is formation of balloon like cytoplasmic droplet. Sperm parametric study exhibits decrease in the total sperm count, sperm motility, forward velocity and increase in the percentage of abnormal sperms in dose dependent manner on treatment benzene extract of Ocimum sanctum leaves. The results suggest that the effects may have resulted from a general disturbance in the proteins and alteration in cauda epididymal milieu probably due to androgen deficiency consequent upon antiandrogenic property of Ocimum sanctum leaves.

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References

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