Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Hesperidin improves warm ischemia/reperfusion-induced oxidative renal injury in rats

  • Gandhi, Chintan (Pharmacy Department, Faculty of Technology and Engineering, M. S. University of Baroda) ;
  • Zalawadia, Rishit (Pharmacy Department, Faculty of Technology and Engineering, M. S. University of Baroda) ;
  • Balaraman, R. (Pharmacy Department, Faculty of Technology and Engineering, M. S. University of Baroda)
  • Published : 2009.12.31
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Abstract

Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. Previous studies showed that antioxidant treatments attenuated renal ischemia/reperfusion injury. The objective of this study was to examine the role of hesperidin in modulating reactive oxygen species induced inflammation and apoptosis after renal ischemia/reperfusion injury. Rats were subjected to right nephrectomy, 15 days later 45 min of renal ischemia and 24 h reperfusion with or without treatment with hesperidin. Renal function, inflammation and apoptosis were compared at 24 h after reperfusion injury. Hesperidin improved the renal dysfunction and reduced inflammation and apoptosis after ischemia/reperfusion injury. In conclusion, hesperidin shows potent anti-apoptotic and antiinflammatory properties due to antioxidant property. These findings may have major implications in the treatment of human ischemic acute renal failure.

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References

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