Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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The protective effect of anti-oxidant in cadmium-induced hair cell death

  • Kim, Su-Jin (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Myung, No-Yil (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Jeong, Hyun-Ja (Biochip Research Center, Hoseo University) ;
  • Um, Jae-Young (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Hyung-Min (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung-Heon (Wonkwang-Oriental Medicines Research Institute and College of Pharmacy, Wonkwang University)
  • Published : 2009.12.31
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Abstract

Cadmium ($Cd^{2+}$) is a heavy metal and a potent carcinogen implicated in tumor development through occupational and environmental exposure. However, the auditory effect of $Cd^{2+}$ is not poorly understood. The purpose of the present study was to investigate whether prevent the ototoxic effects of $Cd^{2+}$ by antioxidnat in auditory cell line, HEI-OC1. Rosmarinic acid is a naturally occurring phenolic compound and also known to possess marked antioxidant properties. We showed that antioxidnat inhibited the the cytochrome c release induced by $Cd^{2+}$. In addition, we showed that the regulatory effect of antioxidnat on apoptosis is through the caspase-9 activation, and extracellular signal-regulated kinase activation in auditory cells. These results suggested antioxidnat its therapeutic usefulness, against $Cd^{2+}$ induced activation of caspase-9 and ERK.

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References

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