Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Effect of Dihydroxybenzoic Acid Isomers on the Analysis of Polyethylene Glycols in MALDI-MS

  • Lee, Ae-Ra (Department of Chemistry, Chungnam National University) ;
  • Yang, Hyo-Jik (Department of Chemistry, Chungnam National University) ;
  • Kim, Yang-Sun (ASTA Inc., Gyeonggi Biocenter) ;
  • Kim, Jeong-Kwon (Department of Chemistry, Chungnam National University)
  • Published : 2009.05.20
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Abstract

The effects of different dihydroxybenzoic acid (DHB) isomers, when used as matrix materials in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), were investigated in analyses of polyethylene glycol (PEG) polymers. PEG polymers ranging from 400 to 8,000 Da were prepared in different DHB isomer matrices using solvent-based and solvent-free methods. PEG samples were detected only in matrices of 2,3-DHB, 2,5-DHB, and 2,6-DHB while the most intense peaks were observed using 2,6-DHB in both solvent-free and solvent-based preparations.

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