Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Thermal Process for Enhancing Mechanical Strength of PLGA Nanoparticle Layers on Coronary Stents

  • Joo, Jae-Ryang (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Nam, Hye-Yeong (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Nam, So-Hee (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Baek, In-Su (School of Chemistry & Molecular Engineering, Seoul National University) ;
  • Park, Jong-Sang (School of Chemistry & Molecular Engineering, Seoul National University)
  • Published : 2009.09.20
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Abstract

Poly (lactic-co-glycolic acid) (PLGA) nanoparticles loading paclitaxel have been deposited on coronary stents by self-assembling properties of colloidal particles. The layers of the nanoparticles were enhanced to a sufficient mechanical strength by a thermal process under the proper temperature and humidity conditions. In vitro release studies proved the controlled paclitaxel release of the nanoparticle layers. This technique gives rise to a new range of applications for nanoparticles and drug-eluting stents.

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