Transactions of the Korean Society of Mechanical Engineers A (대한기계학회논문집A)

The Korean Society of Mechanical Engineers (대한기계학회)
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The Electrode Shape for the Efficient Separation of Cell in Dielectrophoresis-Activated Cell Sorter

유전영동을 이용한 입자분리기의 효율적인 분리를 위한 전극 형태

  • 안재민 (한국한공대학교 항공우주 및 기계공학부) ;
  • 채승엽 (한국한공대학교 항공우주 및 기계공학부) ;
  • 박석호 (전남대학교 기계시스템공학부) ;
  • 김병규 (한국항공대학교, 항공우주 및 기계공학부)
  • Published : 2009.01.01
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Abstract

This paper presents the optimal shape of microelectrode that generates dielectrophoretic(DEP) force to separate particles in homogeneous medium. The principle of the particles sorting is based on the use of the relative strengths of negative DEP (nDEP) and drag forces, as in a general DEP-activated cell sorter (DACS). To numerically calculate the DEP force and drag force, the simulation is implemented in MATLAB 7.0. The properties of particles, which are used in simulation, are similarly selected as those of cells to apply cell separation. The most optimized shape of electrode is selected by numerical simulation according to a variety of electrode shape such as rectangle, trapezoidal, and right-triangle. Through, in addition, parameter study, we found that applied frequency is more significant factor on the separation than various parameters, such as applied voltage and permittivity of medium, that decide on the strength of DEP force.

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References

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