한국축산식품학회지 (Food Science of Animal Resources)

  • 제28권4호
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  • Pages.431-436
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  • 2008
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  • 2636-0772(pISSN)
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  • 2636-0780(eISSN)
한국축산식품학회 (Korean Society for Food Science of Animal Resources)
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BF-7 강화 우유의 뇌기능보호 효과 및 물리화학적 특성

Neuroprotective Effects and Physicochemical Characteristics of Milk Fortified with Fibroin BF-7

  • 최귀헌 (건국대학교 동물생명과학부) ;
  • 조미나 (건국대학교 동물생명과학부) ;
  • 문선희 (건국대학교 동물생명과학부) ;
  • 임성민 (건국대학교 동물생명과학부) ;
  • 정아람 (건국대학교 동물생명과학부) ;
  • 윤여창 (건국대학교 동물생명과학부) ;
  • 백현동 (건국대학교 동물생명과학부)
  • Choi, Gooi-Hun (Division of Animal Life Science, Konkuk University) ;
  • Jo, Mi-Na (Division of Animal Life Science, Konkuk University) ;
  • Moon, Sun-Hee (Division of Animal Life Science, Konkuk University) ;
  • Lim, Sung-Min (Division of Animal Life Science, Konkuk University) ;
  • Jung, A-Ram (Division of Animal Life Science, Konkuk University) ;
  • Yoon, Yoh-Chang (Division of Animal Life Science, Konkuk University) ;
  • Paik, Hyun-Dong (Division of Animal Life Science, Konkuk University)
  • 발행 : 2008.10.31
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초록

The impact of storage on the neuroprotective effects against $A\beta$-induced cell death and physicochemical characteristics of milk fortified with BF-7 were investigated. The BF-7 milk exerted protection of neuronal cells SK-N-SH from amyloid beta ($A\beta$)-induced neuronal stress. Our results showed that incubation of the cell with pretreated BF-7 milk, significantly attenuated apoptotic stress by $A\beta$, considered in cell morphology and nucleus shape. The general compositions were maintained consistently in BF-7 fortified milk (BF-7 milk). The BF-7 did not make any disturbance on pH and titratable acidity. The color change was not detected, either. Also, any microorganism had not been detected with more than 7 days storage at $4^{\circ}C$. In sensory evaluation study. the average scores of each sensory attribute were quite similar with plain milk. In conclusion, our results strongly indicate that BF-7 characteristics are quite adequate to be included in milk and BF-7 milk is still working well on neuro-protection, result in enforcing our brain and delaying neurodegeneration.

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참고문헌

  1. Ban, J. Y., Cho, S. O., Jeon, S. Y., Bae, K. H., Song, K. S., and Seong, Y. H. (2007) 3,4-Dihydroxybenzoic acid from Smilacis chinae rhizome protects amyloid $\beta$ protein (25-35)-induced neurotoxicity in cultured rat cortical neurons. Neurosci. Lett. 420, 184-188 https://doi.org/10.1016/j.neulet.2007.05.009
  2. Barkats, M., Millecamps, S., Abrioux, P., Geoffroy, M. C., and Mallet J. (2000) Overexpression of glutathione peroxidase increases the resistance of neuronal cells to Abetamediated neurotoxicity. J. Neurochem. 75, 1438-1446 https://doi.org/10.1046/j.1471-4159.2000.0751438.x
  3. Blennow, K., De Leon, M. J., and Zetterberg, H. (2006) Alzheimer's disease. Lancet 368, 387-403 https://doi.org/10.1016/S0140-6736(06)69113-7
  4. Boldogh, I. and Kruzel, M. L. (2008) Colostrinintrade mark: an oxidative stress modulator for prevention and treatment of age-related disorders. J. Alzheimers Dis. 13, 303-321 https://doi.org/10.3233/JAD-2008-13308
  5. Chae, H. S., Kang, Y. K., Shin, Y. K., Lee, H. J., Yu, J. I., Lee, K. G., Yeo, J. H., Kim, Y. S., Sohn, D. S., Kim, K. Y., Lee, W. B., Lee, S. H., and Kim, S. S. (2004) The Role of BF-7 on neuroprotection and enhancement of cognitive function. Kor. J. Physiol. Pharmacol. 8, 173-179
  6. Folin, M., Baiguera, S., Fioravanzo, L., Conconi, M. T., Grandi, C., Nussdorfer, G. G., and Parnigotto, P. P. (2006) Caspase-8 activation and oxidative stress are involved in the cytotoxic effect of beta-amyloid on rat brain microvascular endothelial cells. Int. J. Mol. Med. 17, 431-435
  7. Heo H. J. and Lee C. Y. (2006) Phenolic phytochemicals in cabbage inhibit amyloid $\beta$ protein-induced neurotoxicity. LWT - Food Sci. Technol. 39, 331-337 https://doi.org/10.1016/j.lwt.2005.02.018
  8. Ho, Y. S., Yu, M. S., Lai, C. S. W., So, K. F., Yuen, W. H., and Chang R. C. C. (2007) Characterizing the neuroprotective effects of alkaline extract of Lycium barbarum on $\beta$-amyloid peptide neurotoxicity. Brain Res. 1158, 123-134 https://doi.org/10.1016/j.brainres.2007.04.075
  9. Imm, J. Y., Kim, J. G., Kim, J. U., Park, S. O., Oh, S., Kim, Y. J., Chun, H. N., Jung, H. K., You, S., Whang, K. W., and Kim, S. H. (2005) Microbial and nutritional quality of extended shelf life (ESL) milk. Food Sci. Biotechnol. 14, 752-757
  10. Iqbal, K., Alonso, A. C., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C. X., Khatoon, S., Li, B., Liu, F., Rahman, A., Tanimukai, H., and Grundke-Iqbal, I. (2005) Tau pathology in Alzheimer disease and other tauopathies. Biochim. Biophys. Acta 1739, 198-210 https://doi.org/10.1016/j.bbadis.2004.09.008
  11. Ji, Z. N., Dong, T. T. X., Ye, W. C., Choi, R. C., Lo, C. K., and Tsim, K. W. K. (2006) Ginsenoside Re attenuate $\beta$-amyloid and serum-free induced neurotoxicity in PC12 cells. J. Ethnopharmacol. 107, 48-52 https://doi.org/10.1016/j.jep.2006.02.004
  12. Keller, J. N., Hanni, K. B., and Markesbery, W. R. (1999) 4- hydroxynonenal increases neuronal susceptibility to oxidative stress. J. Neurosci. Res. 58, 823-830 https://doi.org/10.1002/(SICI)1097-4547(19991215)58:6<823::AID-JNR9>3.0.CO;2-T
  13. Kim, D. K., Kang, Y. K., Lee, M. Y., Lee, K. G., Yeo, J. H., Lee, W. B., Kim, Y. S., and Kim, S. S. (2005) Neuroprotection and enhancement of learning and memory by BF-7. J. Health Sci. 51, 317-324 https://doi.org/10.1248/jhs.51.317
  14. Kruman, I., Bruce-Keller, A. J., Bredesen, D., Waeg, G., and Mattson, M. P. (1997) Evidence that 4-hydroxynonenal mediates oxidative stress induced neuronal apoptosis. J. Neurosci. 17, 5089-5100 https://doi.org/10.1523/JNEUROSCI.17-13-05089.1997
  15. Lee, J. W. and Lee, Y. C. (2000) The physico-chemical and sensory properties of milk with water soluble chitosan. Korean J. Food Sci. Technol. 32, 806-813
  16. Lee, S. H., Kim, Y. S., Kang, Y. K., Kwon, O. S., Shin, Y. K., Song, J. H., Lee, M. Y., Lee, K. G., Yeo, J. H., Lee, W. B., Lee, T. J., and Kim, S. S. (2004) The improvement of learning and memory ability of normal persons by BF-7. Kor. J. Physiol. Pharmacol. 8, 307-312
  17. Manzi, P., Marconi S., and Pizzoferrato, L. (2007) New functional milk-based products in the Italian market. Food Chem. 104, 808-813 https://doi.org/10.1016/j.foodchem.2006.12.042
  18. Milne, G. L., Morrow, J. D., and Picklo, M. J. Sr (2006) Elevated oxidation of docosahexaenoic acid, 22:6 (n-3), in brain regions of rats undergoing ethanol withdrawal. Neurosci. Lett. 405, 172-174 https://doi.org/10.1016/j.neulet.2006.06.058
  19. Montine, T. J., Milatovic, D., Gupta, R. C., Valyi-Nagy, T., Morrow, J. D., and Breyer, R. M. (2002) Neuronal oxidative damage from activated innate immunity is EP2 receptordependent. J. Neurochem. 83, 463-470 https://doi.org/10.1046/j.1471-4159.2002.01157.x
  20. Musiek, E. S., Cha, J. K., Yin, H., Zackert, W. E., Terry, E. S., Porter, N. A., Montine, T. J., and Morrow, J. D. (2004) Quantification of F-ring isoprostane-like compounds (F4- neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrometric assay. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 799, 95-102 https://doi.org/10.1016/j.jchromb.2003.10.036
  21. Reich, E. E., Markesbery, W. R., Roberts, L. J., Swift, L. L., Morrow, J. D., and Montine, T. J. (2001) Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. Am. J. Pathol. 158, 293-297 https://doi.org/10.1016/S0002-9440(10)63968-5
  22. Shi, G. F., An, L. J., Jiang, B., Guan, S., and Bao, Y. M. (2006) Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo. Neurosci. Lett. 403, 206-210 https://doi.org/10.1016/j.neulet.2006.02.057
  23. Vinderola, G. (2008) Dried cell-free fraction of fermented milks: new functional additives for the food industry. Trends Food Sci. Technol. 19, 40-46 https://doi.org/10.1016/j.tifs.2007.07.003
  24. Wei, Z., Song, M. S., MacTavish, D., Jhamandas, J. H., and Kar, S. (2008) Role of calpain and caspase in $\beta$-amyloidinduced cell death in rat primary septal cultured neurons. Neuropharmacology 54, 721-733 https://doi.org/10.1016/j.neuropharm.2007.12.006
  25. Wisniewski, T. and Konietzko, U. (2008) Amyloid-$\beta$ immunisation for Alzheimer's disease. Lancet Neurol. 7, 805-811 https://doi.org/10.1016/S1474-4422(08)70170-4

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  1. Milk Containing BF-7 Enhances the Learning and Memory, Attention, and Mathematical Ability of Normal Persons vol.29, pp.2, 2009, https://doi.org/10.5851/kosfa.2009.29.2.278
  2. Characterization of tyrosine-rich Antheraea pernyi silk fibroin hydrolysate vol.48, pp.1, 2011, https://doi.org/10.1016/j.ijbiomac.2010.09.020
  3. Effect of a Fibroin Enzymatic Hydrolysate on Memory Improvement: A Placebo-Controlled, Double-Blind Study vol.10, pp.2, 2018, https://doi.org/10.3390/nu10020233
  4. Identification and applications of neuroactive silk proteins: a narrative review vol.17, pp.3, 2008, https://doi.org/10.32725/jab.2019.012