Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Interaction of Apolipoprotein E ${\varepsilon}4$ and Education on Cognitive Decline in Korean Elders

노인의 인지감퇴에 미치는 아포지단백 E4와 교육수준의 상호작용

  • Kim, Jae-Min (Department of Psychiatry, Chonnam National University Medical School) ;
  • Shin, Il-Seon (Department of Psychiatry, Chonnam National University Medical School) ;
  • Kim, Sung-Wan (Department of Psychiatry, Chonnam National University Medical School) ;
  • Yang, Su-Jin (Department of Psychiatry, Chonnam National University Medical School) ;
  • Park, Sang-Wook (Department of Psychiatry, Chonnam National University Medical School) ;
  • Shin, Hee-Young (Clinical Trial Center, Chonnam National University Hospital) ;
  • Yoon, Jin-Sang (Department of Psychiatry, Chonnam National University Medical School)
  • 김재민 (전남대학교 의과대학 정신과학교실) ;
  • 신일선 (전남대학교 의과대학 정신과학교실) ;
  • 김성완 (전남대학교 의과대학 정신과학교실) ;
  • 양수진 (전남대학교 의과대학 정신과학교실) ;
  • 박상욱 (전남대학교 의과대학 정신과학교실) ;
  • 신희영 (전남대학교병원 임상시험센터) ;
  • 윤진상 (전남대학교 의과대학 정신과학교실)
  • Published : 2008.02.29
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Abstract

Objectives : This study aimed to test potential modifying effects of education on the association between apolipoprotein E ${\varepsilon}4$ (Apo E4) and cognitive decline. Methods : A community cohort(N=683) aged 65 or over completed the Korean version of Mini-Mental State Examination(MMSE-K) at baseline and two years later(1999-2001). Apo E polymorphisms were genotyped, and classified into that with or without Apo E4. Educational levels were categorized into people with or without education. Covariates included demographic(age, gender), life style(smoking, alcohol drinking), clinical (depression, sleep disorder, vascular risk factors) characteristics. Results : The association between Apo E4 and cognitive decline was significant only in the old persons with no education. The interaction term between education and Apo E4 on cognitive decline was significant(p=0.040). Conclusion : Elders with no education might be more vulnerable to the impact of Apo E4 on cognitive decline, which suggests gene-environment interaction.

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