Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Nuruk Extract Inhibits Lipopolysaccharide-Induced Production of Nitrite and Interleukin-6 in RAW 264.7 Cells Through Blocking Activation of p38 Mitogen-Activated Protein Kinase

  • Kim, Jong-Eun (Department of Agricultural Biotechnology, Seoul National University) ;
  • Jung, Sung-Keun (Department of Agricultural Biotechnology, Seoul National University) ;
  • Lee, Sang-Jin (Research Laboratory, Kooksoondang Brewery Co., Ltd.) ;
  • Lee, Ki-Won (Department of Bioscience and Biotechnology, Konkuk University) ;
  • Kim, Gye-Won (Research Laboratory, Kooksoondang Brewery Co., Ltd.) ;
  • Lee, Hyong-Joo (Department of Agricultural Biotechnology, Seoul National University)
  • Published : 2008.08.31
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Abstract

Nuruk, which is a natural inoculator and source of amylolytic enzymes, is used in Korean traditional rice wine. A methanol extract of nuruk (NE) attenuated lipopolysaccharide (LPS)-induced nitrite and interleukin (IL)-6 in RAW 264.7 cells. Both the n-hexane and water fractions from NE (MEH and MW, respectively) inhibited the production of nitrite and IL-6 in RAW 264.7 cells. MEH and MW also inhibited the LPS-induced inducible nitric oxide synthase expression. Further, and MEH protected against the LPS-induced activation of p38 mitogen-activated protein kinase. Together, these results indicate that nuruk may contribute to the anti-inflammatory and cancer-preventive effects of Korean traditional rice wine.

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References

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