Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Protective Effect of Sasa Quelpaertensis and p-Coumaric Acid on Ethanol-induced Hepatotoxicity in Mice

  • Lee, Sang-Il (Department of Molecular Medicine, Kyungpook National University School of Medicine) ;
  • An, Sang-Mi (Department of Molecular Medicine, Kyungpook National University School of Medicine) ;
  • Mun, Gyeong-In (Department of Molecular Medicine, Kyungpook National University School of Medicine) ;
  • Lee, Seung-Jin (Department of Molecular Medicine, Kyungpook National University School of Medicine) ;
  • Park, Kwon-Moo (Department of Anatomy, Kyungpook National University School of Medicine) ;
  • Park, Sun-Hong (Onc Co. Ltd.) ;
  • Boo, Yong-Chool (Department of Molecular Medicine, Kyungpook National University School of Medicine)
  • Published : 2008.08.30
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Abstract

Excessive alcohol use causes oxidative stress in the liver, and antioxidant therapy has been an attractive approach for the treatment of ethanol-induced liver damage. The present study examined the hepatoprotective effect of Sasa quelpaertensis Nakai (Korean name, Jeju-Joritdae) in C57BL/6 mice intoxicated with ethanol. Mice were intraperitoneally administered with ethanol alone, or together with test materials three times at 12-h intervals. At 3 h after the last dosing, hepatotoxicity was assessed based on serum activities of aspartate aminotransferase and alanine aminotransferase, and hepatic contents of thiobarbituric acid-reactive substances and glutathione. Sasa quelpaertensis extract mitigated the acute ethanol hepatotoxicity as effectively as silymarin. Its n-butanol fraction was more active than methylene chloride or aqueous fraction. p-Coumaric acid, a major constituent of S. quelpaertensis, was found to effectively prevent the ethanol-induced hepatotoxicity. These data suggest that S. quelpaertensis and p-coumaric acid could be useful for the prevention of liver disease caused by alcohol abuse.

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References

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