Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Preparation of Micronized Anti-dandruff Agents Using Supercritical Carbon Dioxide

초임계 이산화탄소를 이용한 미립 항비듬제 제조

  • Shin, Moon-Sam (School of Chemical & Biological Engineering, Seoul National University)
  • 신문삼 (서울대학교 화학생물공학부)
  • Published : 2008.09.30
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Abstract

Iodopropynyl butylcarbamate and climbazole as anti-dandruff agents widely used in cosmetics and pharmaceutics were micronized using supercritical fluid. Supercritical carbon dioxide was selected due to relatively low critical temperature and critical pressure. Iodopropynyl butylcarbamate and climbazole were chosen because of their solubility in supercritical carbon dioxide. The rapid expansion of supercritical solution (RESS) experiments involved investigations of the effect of pressure, temperature on particle size and morphology.

화장품, 의약품에서 항비듬제로 널리 사용되는 요도프로피닐 부틸카바메이트와 클림바졸을 초임계 유체를 이용하여 미세입자를 제조하였다. 초임계 유체로는 임계온도와 임계압력이 상대적으로 낮은 이산화탄소가 사용되었다. 초임계 이산탄소에 용해력이 있는 요도프로피닐 부틸카마메이트와 클림바졸을 항비듬제로 선택되었다. 초임계 용액 급속팽창법을 이용하여 압력과 온도를 변화시켜 입자크기와 형상에 미치는 영향을 분석하였다.

Keywords

References

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