Food Science and Biotechnology

  • 제17권1호
  • /
  • Pages.156-160
  • /
  • 2008
  • /
  • 1226-7708(pISSN)
  • /
  • 2092-6456(eISSN)
한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지

Calcium Channel-blocking Activity of Chinese Balloon Flower (Platycodon grandiflorum) for Producing Blood Pressure-lowering Functional Foods

  • Kang, Yoon-Seok (Department of Bioscience and Biotechnology, Konkuk University) ;
  • Hong, Kwon-Pyo (Department of Bioscience and Biotechnology, Konkuk University) ;
  • Jung, Dong-Chae (Department of Bioscience and Biotechnology, Konkuk University) ;
  • Hong, Sung-Won (Department of Bioscience and Biotechnology, Konkuk University) ;
  • Lee, Jun-Ho (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) ;
  • Nah, Seung-Yeal (Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University) ;
  • Lim, Yoong-Ho (Department of Bioscience and Biotechnology, Konkuk University) ;
  • Bae, Dong-Ho (Department of Bioscience and Biotechnology, Konkuk University)
  • 발행 : 2008.02.29
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study was conducted to evaluate the hypotensive properties of the extract of Chinese balloon flower (Platycodon grandiflorum)'s root. In the studies for calcium channel-blocking using Xenopus oocytes, the ethanol-extract ($26.2{\pm}5.2%$) showed higher activity than water-extract. Twenty female rats were fed 25, 35, and 45 mg/kg BW/day of the ethanol-extract for 14 days to observe the changes in blood pressures and heart pulses. Ethanol-extract decreased the systolic, diastolic, and mean blood pressures of the rats. Especially, the rats fed with 45 mg/kg BW/day of the ethanol-extract showed significant decreases in the blood pressures. These results suggested that a decrease in blood pressures was due to the extension of a blood vessel with calcium channel-blocking by ethanol-extract of Chinese balloon flower. Forty %-ethanol showed the highest efficiency for ethanol-extraction of Chinese balloon flower.

키워드

참고문헌

  1. Bers DM. Excitation-Contraction Coupling and Cardiac Contractile Force. Kluwer Academic, Dordrecht, Netherlands. pp. 26-27 (1991)
  2. Katz AM. Physiology of Heart. 2nd ed. Raven Press, New York, NY, USA. pp. 35-38 (1992)
  3. Bolton RB. Mechanism of action or transmitters and other substances on smooth muscle. Physiol. Rev. 59: 606-718 (1979) https://doi.org/10.1152/physrev.1979.59.3.606
  4. Godfraind T. Alternative mechanism for the potentiation of the relaxation evoked by isoprenaline in aortae from young and aged rats. Eur. J. Pharmacol. 53: 273-279 (1979) https://doi.org/10.1016/0014-2999(79)90133-X
  5. Furchgott RF. Sprial-cut strip of rabbit aorta for in vitro studies of response of arterial smooth muscle. Method Med. Res. 8: 177-186 (1976)
  6. Reuter H, Beeler GW. Calcium current and activation of contraction in ventricular myocardial fibres. Science 162: 399-401 (1969)
  7. Zhang YJ. Application and progress of calcium antagonist. Prog. Cardioangiol. 16: 43-51 (1995)
  8. Fleckenstein A, Tritthart FB, Herbst A, Grun G. A new group of competitive Ca-antagonist (Iproveratril, D600, prenylamine) with highly potent inhitory effect on excitation-contraction coupling in mammalian myocardium. Pflueg. Arch. Eur. J. Phy. 307: R25-R32 (1969)
  9. Godfraind T. Actions of Nifedipine on calcium fluxes and contraction in isolated ratarteries. J. Pharmacol. Exp. Ther. 224: 443-450 (1983)
  10. Godfraind T, Dieu D. The inhibition by flunarizine of the norepinephine-evoked contraction and calcium influx in rat aorta and mesenteric arteies. J. Pharmacol. Exp. Ther. 217: 510-515 (1881)
  11. Godfraind T, Miller RC. Specificity of actions of Ca entry blockers, a comparision of their actions in rat arteries and in human coronary. Circ. Res. 43: 251-256 (1983)
  12. Godfraind T, Govoni S. Recent advances in the pharmacology of $Ca^{++}$ and $K^{+}$ channels. J. Pharmacol. Sci. 16: 1-4 (1995)
  13. Shimizu Y, Kataoka M, Seto H, Kido J, Nagata T. Nifedipine induces gingival epithelial hyperplasia in rats through inhibition of apoptosis. J. Periodontol. 73: 863-867 (2002)
  14. Kanamasa K, Kimura A, Miyataka M. Incidence of cancer in postmyocardial infarction patients treated with short-acting nifedipine and diltiazem, secondary prevention group. Cancer 85: 1369-1374 (1996) https://doi.org/10.1002/(SICI)1097-0142(19990315)85:6<1369::AID-CNCR21>3.0.CO;2-5
  15. Kerekgyarto C, Virag L, Chihara G, Fachet J. Strain differences in the cytotoxic activity and TNF production of murine macrophages stimulated by lentinan. Int. Immunopharmacol. 18: 347-353 (1996) https://doi.org/10.1016/S0192-0561(96)00038-0
  16. Han S-B, Kim Y-H, Lee C-W, Park S-M, Lee H-Y, Ahn K-S. Characteristic imunostimulation by angelan isolated from Angelica gigas Nakai. Int. Immunopharmacol. 40: 39-48 (1998) https://doi.org/10.1016/S0162-3109(98)00026-5
  17. Liu F, Fung MC. Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides. Life Sci. 64: 39-48 (1999)
  18. Mark SP, Woo M-N, Vuksan VM. Korean red ginseng lowers blood pressure in individuals with hypertension. Am. J. Hypertens. 17: 33- 38 (2004)
  19. Hah J-S, Kang B-S, Kang D-H. Effect of Panax Ginseng alcohol extract on cardiovascular system. Yonsei Med. J. 19: 2-9 (1978)
  20. Seog H-M, Jung C-H, Kim Y-S, Park S-H. Phenolic acids and antioxidant activities of wild ginseng (Panax ginseng C.A. Meyer) leaves. Food Sci. Biotechnol. 14: 371-374 (2005)
  21. Lee E-B. A comparison of experimental pharmacological effects of crude platycodin with clinical indication of Platycodi radix. J. Pharm. Soc. Jpn. 93: 1188-1194 (1973) https://doi.org/10.1248/yakushi1947.93.9_1188
  22. Kim K-S, Ezaki O, Ikemoto S, Hitakura M. Effects of Platycodon grandiflorum feeding on serum and liver lipid concentrations in rats with diet-induced hyperlipidemia. J. Nutr. Sci. 41: 485-491 (1995)
  23. Kim K-S, Seo E-K, Lee Y-C, Lee T-Y, Cho Y-W, Ezaki O, Kim CH. Effect of dietary Platycodon grandiflorum on the improvement of insulin resistance in obese Zucker rats. J. Nutr. Biochem. 11: 420- 424 (2000) https://doi.org/10.1016/S0955-2863(00)00098-X
  24. Lee Y-H, Kim Y-J, Kim H-I, Cho H-Y, Yoon G-H. Potent HAT inhibitory effect of aqueous extract from bellflower (Platycodon grandiflorum) roots on androgen receptor-mediated transcriptional regulation. Food Sci. Biotechnol. 16: 457-462 (2007)
  25. Jeong S-M, Lee J-H, Yoon I-S, Nah S-Y. Gene cloning, tissue distribution, and its characterization of $Ca^{++}$-activated $Cl^{-}$ channel activated by ginsenosides in Xenopus laevis oocytes. J. Ginseng Res. 29: 167-175 (2005) https://doi.org/10.5142/JGR.2005.29.4.167
  26. Kubota Y, Umegaki K, Kagota S, Tanaka N, Nakamura K, Kunitomo M, Shinozuka K. Evaluation of blood pressure measured by tail-cuff methods (without heating) in spontaneously hypertensive rats. Biol. Pharm. Bull. 29: 1756-1758 (2006) https://doi.org/10.1248/bpb.29.1756
  27. Sung H-Y, Lim Y-J, Choi Y-S. Soy isoflavones do not alter the effects of fructooligosaccharide on the intestinal ecosystem of colon-cancer model rats. Food Sci. Biotechnol. 15: 931-936 (2006)
  28. Sonkusare S, Palade PT, Marsh JD, Telemaque S, Pesic A, Rusch NJ. Vascular calcium channels and high blood pressure: Pathophysiology and therapeutic implications. Vasc. Pharmacol. 44: 131- 142 (2006) https://doi.org/10.1016/j.vph.2005.10.005
  29. Harder DR, Brann L, Halpern W. Altered membrane electrical properties of smooth muscle cells from small cerebral arteries of hypertensive rats. Blood Vessels 20: 154-160 (1983)
  30. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: A metaanalysis in individual data for one million adults in 61 prospective studies. Prospective studies collaboration. Lancet 360: 1903-1913 (2002) https://doi.org/10.1016/S0140-6736(02)11911-8
  31. Franklin SS, Gustin W, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D. Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation 96: 308- 315 (1997) https://doi.org/10.1161/01.CIR.96.1.308
  32. Franklin SS, Gustin W, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D. Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation 103: 1245-1249 (2001) https://doi.org/10.1161/01.CIR.103.9.1245
  33. Lim D-Y, Kim B-C, Lee E-B. Comparison of vasodilator effect of Platycodin D and D3 in rats. Korean J. Physiol. Pharmacol. 7: 149- 155 (2003)
  34. Fatehi M, Rashidabady T, Zahra FH. Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J. Ethnopharmacol. 84: 199-203 (2003) https://doi.org/10.1016/S0378-8741(02)00299-4