Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Improved Dissolution of Solid Dispersed Atorvastatin Using Spray-Dryer

분무건조기를 이용한 아토르바스타틴 고체분산체의 용출율 개선

  • Lee, Jun-Hee (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Kim, Dae-Sung (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Kim, Won (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Park, Jong-Hak (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Ahn, Sik-Il (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Kim, Yun-Tae (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Rhee, John-M. (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University) ;
  • Khang, Gil-Son (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
  • 이준희 (전북대학교 BK-21 고분자 BIN 융합연구팀) ;
  • 김대성 (전북대학교 BK-21 고분자 BIN 융합연구팀) ;
  • 김원 (전북대학교 BK-21 고분자 BIN 융합연구팀) ;
  • 박종학 (전북대학교 BK-21 고분자 BIN 융합연구팀) ;
  • 안식일 (전북대학교 BK-21 고분자 BIN 융합연구팀) ;
  • 김윤태 (전북대학교 BK-21 고분자 BIN 융합연구팀) ;
  • 이종문 (전북대학교 BK-21 고분자 BIN 융합연구팀) ;
  • 강길선 (전북대학교 BK-21 고분자 BIN 융합연구팀)
  • Published : 2008.08.20
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Abstract

Solid dispersions of poorly water-soluble drug, atorvastatin, were prepared with Eudragit L100 to improve the solubility by spray dryer. To investigate the correlation between physicochemical properties and dissolution rate of solid dispersions, the samples were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC) and fourier transform infrared spectroscopy (FT-IR). SEM and DSC were found that atorvastatin is amorphous in the Eudragit L100 solid dispersion. FT-IR was used to analyze the salt formation by interaction between atorvastatin and Eudragit L100. The dissolution rate of solid dispersed atorvastatin was markedly increased compared to drug powder in stimulated intestinal juice (pH 6.8). Thus, the solid dispersed atorvastatin using the spray drying method with Eudragit L100 may be effective for the bioavailability.

Keywords

References

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