대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제29권1호
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- Pages.32-41
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- 2008
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- 1226-9174(pISSN)
한국인 천식환자의 Monocyte chemoattractant protein 1(MCP-1) 유전자 다형성에 대한 분석
Analysis of Monocyte Chemoattractant Protein 1(MCP-1) Polymorphism in Korean Patients with Asthma
- 황우석 (경희대학교 한의과대학 폐계내과학 교실) ;
- 정승연 (경희대학교 한의과대학 폐계내과학 교실) ;
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김진주
(경희대학교 약학대학 한방생리학교실) ;
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정희재
(경희대학교 한의과대학 폐계내과학 교실) ;
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정승기
(경희대학교 한의과대학 폐계내과학 교실)
- Hwang, Woo-Suk (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung-Hee University) ;
- Jeong, Seung-Yeon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung-Hee University) ;
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Kim, Jin-Ju
(Dept. of Oriental Physiology, College of Pharmacy, Kyung-Hee University) ;
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Jung, Hee-Jae
(Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung-Hee University) ;
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Jung, Sung-Ki
(Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine College of Oriental Medicine, Kyung-Hee University)
- 발행 : 2008.03.31
초록
Background : Monocyte chemoattractant protein-1(MCP-1), one of the CC chemokines, appears to play a significant role in asthma pathogenesis. It was reported that polymorphism in the MCP-1(-2518 A/G promoter) was associated with asthma in Caucasians, but the association of this polymorphism and asthma patients in the Korean population has not yet been clarified. Objective : We investigated the possible association between 2 polymorphisms (-2518 A/G promoter and Cys35Cys) and asthma patients in a Korean population. Materials and Methods : DNA samples were obtained from 86 Korean asthma patients and 270 healthy controls. MCP-1 genomic variants (-2518 A/G promoter and Cys35Cys polymorphism) were detected by PCR-RFLP. Level of MCP-1 was measured by ELISA for each genotype (n=8) (AA, AG, GG) and allele types of -2518 A/G promoter polymorphism for control subjects. Results : The Cys35Cys polymorphism was associated with asthma patients in Korean population [genotype distribution (