Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Production of 1,5-Dihydroxy-3-Methoxy-7-Methylanthracene-9,10-Dione by Submerged Culture of Shiraia bambusicola

  • Cai, Yujie (Key Laboratory of Industrial Biotechnology, Jiangnan University) ;
  • Ding, Yanrui (School of Information Technology, Jiangnan University) ;
  • Tao, Guanjun (Testing & Analysis Center, Jiangnan University) ;
  • Liao, Xiangru (School of Biotechnology, Jiangnan University)
  • Published : 2008.02.29
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Abstract

1,5-Dihydroxy-3-methoxy-7-methylanthracene-9,10-dione (shiraiarin) is a kind of antitumor and antibacterial anthraquinone, and was produced for the first time from the submerged fermentation of Shiraia bambusicola, as confirmed by ESI-MS and NMR. The production of shiraiarin was significantly influenced when varying the carbon source, and a high amount of shiraiarin was only achieved when using lactose. The production of shiraiarin was also stimulated when using $NaNO_3$ as the nitrogen source, whereas other nitrogen sources inhibited its production. Shiraiarin was formed during the stationary phase with a pH value higher than 8. The production of shiraiarin was inhibited by sporulation.

Keywords

References

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