Lactic Acid Bacterial Fermentation Increases the Antiallergic Effects of Ixeris dentata

  • 발행 : 2008.02.29

초록

Ixeris dentata (ID, family Asteraceae), called Seumbakuy in Korea, was fermented with lactic acid bacteria (LAB) and their antiallergic activities were investigated. Fermentation of ID with Bifidobacterium breve or Lactobacillus acidophilus increased its inhibition of degranulation in RBL-2H3 cells induced by the IgE-antigen complex. Oral administration of these extracts to mice inhibited the passive cutaneous anaphylaxis (PCA) reaction induced by the IgE-antigen complex and scratching behaviors induced by compound 48/80. The fermented ID more potently inhibited the PCA reaction and scratching behaviors than the non-fermented one. These extracts also inhibited mRNA expression of TNF-${\alpha}$ and IL-4, as well as NF-${\kappa}B$ activation in RBL-2H3 cells induced by the IgE-antigen complex. These findings suggest that LAB fermentation improves ID-mediated inhibition of IgE-induced allergic diseases such as rhinitis and asthma, and that ID works by inhibiting degranulation and NF-${\kappa}B$ activation in mast cells and basophils.

키워드

참고문헌

  1. Bae, E. A., S. Y. Park, and D. H. Kim. 2000. Constitutive $\beta - glucosidases$ hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol. Pharm. Bull. 23: 1481-1485 https://doi.org/10.1248/bpb.23.1481
  2. Bielory, L. 2004. Complementary and alternative interventions in asthma, allergy, and immunology. Ann. Allergy Asthma Immunol. 93(2 Suppl 1): S45-S54 https://doi.org/10.1016/S1081-1206(10)61486-X
  3. Choi, J., K. Kim, Y. Kim, M. J. Park, Y. S. Lee, and D. Jeoung. 2006. Fractions of Chamaecyparis obtusa display antiallergic effect in RBL2H3 cells. J. Microbiol. Biotechnol. 16: 1747-1752
  4. Choo, M. K., E. K. Park, M. J. Han, and D. H. Kim. 2003. Antiallergic activity of ginseng and its ginsenoside. Planta Med. 69: 518-522 https://doi.org/10.1055/s-2003-40653
  5. Chung, H. S., H. J. Jeong, M. J. Han, S. T. Park, K. K. Seong, S. H. Baek, D. M. Jeong, M. J. Kim, and H. M. Kim. 2002. Nitric oxide and tumor necrosis factor-alpha production by Ixeris dentata in mouse peritoneal macrophages. J. Ethnopharmacol. 82: 217-222 https://doi.org/10.1016/S0378-8741(02)00188-5
  6. Friedman, E. S., N. LaNatra, and M. J. Stiller. 2002. NSAIDs in dermatologic therapy: Review and preview. J. Cutan. Med. Surg. 6: 449-459 https://doi.org/10.1007/s10227-001-0137-3
  7. Furumoto, Y., S. Nunomura, T. Terada, J. Rivera, and C. Ra. 2004. The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. J. Biol. Chem. 279: 49177-49187 https://doi.org/10.1074/jbc.M404730200
  8. Ito, H., T. Miyazaki, M. Ono, and H. Sakurai. 1998. Antiallergic activities of rabdosiin and its related compounds: Chemical and biochemical evaluations. Bioorg. Med. Chem. 6: 1051-1056 https://doi.org/10.1016/S0968-0896(98)00063-7
  9. Jiang, J. S., C. M. Shih, S. H. Wang, T. T. Chen, C. N. Lin, and W. C. Ko. 2006. Mechanisms of suppression of nitric oxide production by 3-O-methylquercetin in RAW 264.7 cells. J. Ethnopharmacol. 2103: 281-287
  10. Kempuraj, D., M. Huang, K. Kandere-Grzybowska, S. Basu, W. Boucher, R. Letourneau, A. Athanassiou, and T. C. Theoharides. 2003. Azelastine inhibits secretion of IL-6, TNF-alpha, and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells. Int. Arch. Allergy Immunol. 132: 231-239 https://doi.org/10.1159/000074304
  11. Kim, D. H. 2002. Herbal medicines are activated by intestinal microflora. Nat. Prod. Sci. 8: 35-43
  12. Kim, H. and G. E. Ji. 2006. Effect of viability and integrity of Bifidobacterium on suppression of allergy in mice. J. Microbiol. Biotechnol. 16: 1010-1016
  13. Kobashi, K. and T. Akao. 1997. Relation of intestinal bacteria to pharmacological effects of glycosides. Biosci. Microflora 16: 1-7 https://doi.org/10.12938/bifidus1996.16.1
  14. Mastuda, H., T. Morikawa, K. Ueda, H. Managi, and M. Yoshikawa. 2002. Structural requirement of flavonoids for inhibition of antigen-induced degranulation, $TNF-\alpha$ and IL-4 production from RNL-2H3 cells. Bioorg. Med. Chem. 10: 2123-2128
  15. Mican, J. A., N. Arora, P. R. Burd, and D. D. Metcalfe. 1992. Passive cutaneous anaphylaxis in mouse skin is associated with local accumulation of interleukin-6 mRNA and immunoreactive interleukin-6 protein. J. Allergy Clin. Immunol. 90: 815-824 https://doi.org/10.1016/0091-6749(92)90107-D
  16. Mitre, E. and T. B. Nutman. 2006. Basophils, basophilia and helminth infections. Chem. Immunol. Allergy 90: 141-156
  17. Nyman, M. 1995. Effects of processing on dietary fibre in vegetables. Eur. J. Clin. Nutr. 49 (Suppl 3): S215-S218
  18. Oh, S. H., T. H. Sung, and M. R. Kim. 2003. Ixeris dentata extract maintains glutathione concentrations in mouse brain tissue under oxidative stress induced by kainic acid. J. Med. Food 6: 353-358 https://doi.org/10.1089/109662003772519912
  19. Park, H. Y., E. A. Bae, M. J. Han, E. C. Choi, and D. H. Kim. 1998. Inhibitory effects of Bifidobacterium spp. isolated from a healthy Korean on harmful enzymes of human intestinal microflora. Arch. Pharm. Res. 21: 54-61 https://doi.org/10.1007/BF03216753
  20. Sakuma, S., Y. Higashi, N. Sato, T. Sasakawa, T. Sengoku, Y. Ohkubo, T. Amaya, and T. Goto. 2001. Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system (comparison with steroids). Int. Immunopharmacol. 1: 1219-1226 https://doi.org/10.1016/S1567-5769(01)00059-5
  21. Schafer-Korting, M., M. H. Schmid, and H. C. Korting. 1996. Topical glucocorticoids with improved risk-benefit ratio. Drug Safety 14: 375-385 https://doi.org/10.2165/00002018-199614060-00003
  22. Shin, Y. W., E. A. Bae, S. S. Kim, Y. C. Lee, and D. H. Kim. 2005. Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis. Int. Immunopharmacol. 5: 1183-1191 https://doi.org/10.1016/j.intimp.2005.02.016
  23. Shin, Y. W., E. A. Bae, B. Lee, S. Min, N. I. Baek, S. N. Ryu, H. G. Chung, and D. H. Kim. 2006. Effect of fermented lactic acid bacteria on antiallergic effect of Artemisia princeps pampanini. J. Microbiol. Biotechnol. 16: 1464-1467
  24. Simons, F. E. R. 1992. The antiallergic effects of antihistamines (H1-receptor antagonists). J. Allergy Clin. Immunol. 90: 705-715 https://doi.org/10.1016/0091-6749(92)90156-V
  25. Soka, T. 1985. Ixeris dentata. In: Dictionary of Chinese Drugs, 1st Ed. Shanghai Science Technology Shogakukan Press, Tokyo
  26. Stevens, R. L. and K. F. Austen. 1989. Recent advances in the cellular and molecular biology of mast cells. Immunol. Today 10: 381-386 https://doi.org/10.1016/0167-5699(89)90272-7
  27. Steinkraus, K. H. 1983. Lactic acid fermentation in the production of foods from vegetables, cereals and legumes. Antonie Van Leeuwenhoek 49: 337-348 https://doi.org/10.1007/BF00399508
  28. Sugimoto, Y., K. Umakoshi, N. Nojiri, and C. Kamei. 1998. Effect of histamine H1 receptor antagonists on compound 48/ 80-induced scratching behavior in mice. Eur. J. Pharmacol. 351: 1-5 https://doi.org/10.1016/S0014-2999(98)00288-X
  29. Wuthrich, B. 1989. Epidemiology of the allergic diseases: Are they really on the increase? Int. Arch. Allergy Appl. Immunol. 90 (Suppl. 1): 3-10 https://doi.org/10.1159/000235067
  30. Yi, J. M., S. H. Hong, H. J. Lee, J. H. Won, J. M. Kim, D. M. Jeong, S. H. Baek, J. P. Lim, and H. M. Kim. 2002. Ixeris dentata green sap inhibits both compound 48/80-induced anaphylaxis-like response and IgE-mediated anaphylactic response in murine model. Biol. Pharm. Bull. 25: 5-9 https://doi.org/10.1248/bpb.25.5
  31. Zhao, W., C. A. Oskeritzian, A. L. Pozez, and L. B. Schwartz. 2005. Cytokine production by skin-derived mast cells: Endogenous proteases are responsible for degradation of cytokines. J. Immunol. 175: 2635-2642 https://doi.org/10.4049/jimmunol.175.4.2635