YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Inhibition of Nitric Oxide Production by the Extracts of Hibiscus manihot

황촉규 추출물의 Nitric Oxide 생성 저해활성

  • 박은영 (숙명여자대학교 약학대학) ;
  • 양기숙 (숙명여자대학교 약학대학)
  • Published : 2008.08.31
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Abstract

Anti-inflammatory activity of the extracts of Hibiscus manihot was investigated through the evaluation of its inhibitory effect on the production of inflammatory biomarkers (i-NOS, COX-2) in RAW264.7 murine macrophage cells. Among the sequential solvent fractions (hexane, dichloromethane, ethyl acetate, n-butanol and water), the fractions of dichloromethane (1 ${\mu}g/ml$) and ethyl acetate (5 ${\mu}g/ml$) showed potential inhibitory activities on i-NOS and COX-2 activity in RAW264.7 cells. These results suggest that Hibiscus manihot might have an anti-inflammatory activity through the suppression of inflammatory markers.

Keywords

References

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