Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Inhibitory Effect of Oyster Conchioloin on Pro-inflammatory Mediator in Lipopolysaccharide;Activated Raw 264.7 Cells

모려로부터 추출된 conchiolin의 LPS로 유도된 RAW 264.7 세포에서의 항염증 효과

  • 박상미 (대구한의대학교 한의과대학 한방신약개발팀) ;
  • 조용걸 (목단강의대) ;
  • 이종록 (대구한의대학교 한의과대학) ;
  • 이철원 ((주)서진바이오텍) ;
  • 김학주 ((주)서진바이오텍) ;
  • 권영규 (대구한의대학교 한의과대학 한방신약개발팀) ;
  • 김상찬 (대구한의대학교 한의과대학 한방신약개발팀)
  • Published : 2008.08.25
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Abstract

Conchiolin is a complex protein which is secreted by the mollusc's outer epithelium to be the organic basis of mollusc shell. This study is to investigate a potential anti-inflammatory activity of conchiolin of oyster shell (COS). We tested the effects of COS on the lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and prostaglandin E2 (PGE 2) in a murine macrophage cell line, RAW 264.7. COS inhibited production of NO and PGE2 in a dose dependent manner and also decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) and interleukin-6 (IL-6). These results suggest that COS can inhibit production of pro-inflammatory mediators and might be a useful source to treat inflammation.

Keywords

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