대한본초학회지 (The Korea Journal of Herbology)
- 제23권2호
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- Pages.111-121
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- 2008
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
황기의 재배년차(栽培年差)에 따른 천식(喘息)의 면역학적 치료효과에 대한 비교연구
Comparative Study of the Effect m Immune Cure Against Asthma of Astragali Radix by Culturing Year
- Lee, Min-Hyung (Dept. of Herbology, College of Oriental Medicine, Daejeon University) ;
- Roh, Seong-Soo (Dept. of Herbology, College of Oriental Medicine, Daegu Haany University) ;
- Seo, Young-Bae (Dept. of Herbology, College of Oriental Medicine, Daejeon University)
- 발행 : 2008.06.30
초록
Objectives : The present study was carried out to investigate the effects of Astragali radix on the asthma treatment. EAR-I is an extract of astragali radix cultured for one year and EAR-III is an extract of astragali radix cultured for three years. Methods : Two asthma-induced groups mice group was treated respectively with EAR- I and EAR- III. The other group was not. Each group was analyzed in vivo and in vitro experiments. Results : In asthma-induced mice by OVA treatment, the weight of lung, total cell number of leukocyte and eosinophil in BALF, both EAR- I and EAR- III treated groups were significantly decreased compared to control group. IL-4, IL-5, IL-13, histamine, IgE in BLAF of group treated with both EAR-I and EM-III were significantly decreased compared to control group. In FACS analyzing, granulocytes,