폐결핵의 치료 중에 발생한 일시적인 방사선학적 악화를 보인 1예: 초기 CT 소견

A Case of Transient Radiographic Progression during Treatment of Pulmonary Tuberculosis: Early CT Findings

  • 유승민 (포천중문의과대학교 분당차병원 영상의학교실) ;
  • 이화연 (중앙대학교 의과대학 용산병원 영상의학교실)
  • Yoo, Seung Min (Department of Diagnostic Radiology, Pochon Cha University College of Medicine) ;
  • Lee, Hwa Yeon (Department of Diagnostic Radiology, Chung-Ang University College of Medicine)
  • 투고 : 2008.06.13
  • 심사 : 2008.06.17
  • 발행 : 2008.10.30

초록

본 증례에서 폐결핵의 치료 중에 발생한 일시적인 방사선학적 악화의 초기 CT 소견은 폐 주변부에 발생한 폐소엽간 혹은 폐소엽 내 중격비후, 그리고 미세결절들이었다. 후기 CT 소견은 폐 주변부에 위치하고 내부에 저음영을 가지며 조영 증강이 잘되는 폐결절이었다. 폐결핵을 처음 치료하는 젊은 환자에서 임상적인 악화 없이 이러한 CT 소견이 보일 때 일시적인 방사선학적 악화를 의심해야 한다.

Early CT findings of transient radiographic progression (TRP) during treatment of active pulmonary tuberculosis including subpleural, interlobular or intralobular septal thickening and micronodules are shown in the present case. Late CT findings of TRP are subpleural, enhancing nodular infiltration with internal low attenuation. These CT features accompanied by a lack of clinical worsening in young patients taking antituberculous medication due to pulmonary tuberculosis can help to differentiate TRP from other disease entities.

키워드

참고문헌

  1. Urakami E. Differential diagnosis of tuberculosis: a relapse of tuberculosis in the early stage of chemotherapy. Kekkaku 1982;57:544-8.
  2. Sato H, Oizumi K, Motomiya M, Konno K. Reversible roentgenographic progression in the treatment of pulmonary tuberculosis. Kekkaku 1982;57:425-7.
  3. Onwubalili JK, Scott GM, Smith H. Acute respiratory distress related to chemotherapy of advanced pulmonary tuberculosis: a study of two cases and review of the literature. Q J Med 1986;59:599-610.
  4. Akira M, Sakatani M, Ishikawa H. Transient radiographic progression during initial treatment of pulmonary tuberculosis: CT findings. J Comput Assist Tomogr 2000;24:426-31. https://doi.org/10.1097/00004728-200005000-00014
  5. Lee CH, Kim WJ, Yoo CG, Kim YW, Han SK, Shim YS, et al. Response to empirical anti-tuberculosis treatment in patients with sputum smear-negative presumptive pulmonary tuberculosis. Respiration 2005;72:369-74. https://doi.org/10.1159/000086250
  6. Iwai K, Kino C, Tsuchiya S, Kita R, Kinoshita T. Histological observation on the tuberculous lesions aggravated during rifampicin treatment. Kekkaku 1979;54:473-8.
  7. Bobrowitz ID. Reversible roentgenographic progression in the initial treatment of pulmonary tuberculosis. Am Rev Respir Dis 1980;121:735-42.
  8. Choi YW, Jeon SC, Seo HS, Park CK, Park SS, Hahm CK, et al. Tuberculous pleural effusion: new pulmonary lesions during treatment. Radiology 2002;224:493-502. https://doi.org/10.1148/radiol.2242011280
  9. Canetti G. Present aspects of bacterial resistance in tuberculosis. Am Rev Respir Dis 1965;92:687-703.
  10. Blumberg HM, Burman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN, et al. American Thoracic Society/Center for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J RespirCrit Care Med 2003;167:603-62. https://doi.org/10.1164/rccm.167.4.603