폐렴과 급성 호흡부전으로 나타난 흉막의 고립성 섬유성 종양 1예

A Case of a Solitary Fibrous Tumor of the Pleura Presenting as Pneumonia and Acute Respiratory Failure

  • 박혜선 (한양대학교 의과대학 내과학교실) ;
  • 곽현정 (한양대학교 의과대학 내과학교실) ;
  • 박동원 (한양대학교 의과대학 내과학교실) ;
  • 구태연 (한양대학교 의과대학 내과학교실) ;
  • 김혜영 (한양대학교 의과대학 내과학교실) ;
  • 박소연 (한양대학교 의과대학 내과학교실) ;
  • 안성은 (한양대학교 의과대학 내과학교실) ;
  • 김상헌 (한양대학교 의과대학 내과학교실) ;
  • 김태형 (한양대학교 의과대학 내과학교실) ;
  • 손장원 (한양대학교 의과대학 내과학교실) ;
  • 정원상 (한양대학교 의과대학 흉부외과학교실) ;
  • 윤호주 (한양대학교 의과대학 내과학교실) ;
  • 신동호 (한양대학교 의과대학 내과학교실) ;
  • 박성수 (한양대학교 의과대학 내과학교실)
  • Park, Hye Sun (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kwak, Hyun Jung (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Park, Dong Won (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Koo, Tai Yeon (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Hye Young (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Park, So Yeon (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Ahn, Seong Eun (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Sang-Heon (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Tae Hyung (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Sohn, Jang Won (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Chung, Won Sang (Department of Thoracic and Cardiovascular Surgery, Hanyang University College of Medicine) ;
  • Yoon, Ho Joo (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Shin, Dong Ho (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Park, Sung Soo (Department of Internal Medicine, Hanyang University College of Medicine)
  • 투고 : 2008.07.22
  • 심사 : 2008.07.31
  • 발행 : 2008.10.30

초록

흉막의 고립성 섬유성 종양은 주로 흉막통, 호흡곤란, 기침 등의 증상으로 발현하거나 무증상으로 발견되는 경우가 대부분이다. 본 증례의 환자는 흉막의 고립성 섬유성 종양의 거대한 종괴 영향에 의한 압박증상과 동반된 폐렴, 패혈 쇼크와 급성 호흡곤란의 진행으로 매우 치명적인 임상 양상을 보였으며, 기계환기법과 항생제, 승압제 등의 치료 후에 종양절제술로 호전되었다. 저자들은 흉막의 고립성 섬유성 종양으로 인한 치명적인 임상 경과를 보인 증례 1예를 경험하였기에 문헌고찰과 함께 보고한다.

Solitary fibrous tumors of the pleura (SFTPs) are relatively rare tumors that originate from the mesenchymal cells of the submesothelial tissue of the pleura. Patients with SFTPs are often asymptomatic, while some patients experience pleuritic chest pain, cough and/or dyspnea. We report here on a case of SFTP, and the patient presented with septic shock and respiratory failure that required mechanical ventilation. A 68-year-old woman was admitted for the evaluation of her dyspnea and generalized edema. Chest imaging studies showed an 18 cm-sized voluminous mass occupying the right thoracic cavity with anterior displacement of hilar structures and atelectasis of the right lung. Immediately after admission, she developed pneumonia and septic shock that required antibiotics and mechanical ventilation. She displayed a partial response to medical treatment, and then complete excision of the tumor was performed and the pathologic examination revealed benign SFTP. Afterward, she fully improved without evidence of recurrence until now.

키워드

참고문헌

  1. Klemperer P, Coleman BR. Primary neoplasms of the pleura: a report of five cases. Am J Ind Med 1992;22:1-31. https://doi.org/10.1002/ajim.4700220102
  2. de Perrot M, Fischer S, Brundler MA, Sekine Y, Keshavjee S. Solitary fibrous tumors of the pleura. Ann Thorac Surg 2002;74:285-93. https://doi.org/10.1016/S0003-4975(01)03374-4
  3. Okike N, Bernatz PE, Woolner LB. Localized mesothelioma of the pleura: benign and malignant variants. J Thorac Cardiovasc Surg 1978;75:363-72.
  4. Briselli M, Mark EJ, Dickersin GR. Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature. Cancer 1981;47:2678-89. https://doi.org/10.1002/1097-0142(19810601)47:11<2678::AID-CNCR2820471126>3.0.CO;2-9
  5. Sung SH, Chang JW, Kim J, Lee KS, Han J, Park SI. Solitary fibrous tumors of the pleura: surgical outcome and clinical course. Ann Thorac Surg 2005;79:303-7. https://doi.org/10.1016/j.athoracsur.2004.07.013
  6. Torre W, Rodriguez-Spiteri N, Sola JJ, Delgado M. Localized fibrous tumors of the pleura: experience with 7 recent cases. Arch Bronconeumol 2004;40:329-32.
  7. Shaker W, Meatchi T, Dusser D, Riquet M. An unusual presentation of solitary fibrous tumour of the pleura: right atrium and inferior vena cava compression. Eur J Cardiothorac Surg 2002;22:640-2. https://doi.org/10.1016/S1010-7940(02)00432-3
  8. Chang JC, Su KY, Chao SF, Hsu YH, Yang GG, Chang BS. Hypoglycemia in a patient with a huge malignant solitary fibrous tumor of the pleura. Pathol Int 2007;57:791-3. https://doi.org/10.1111/j.1440-1827.2007.02175.x
  9. Robinson LA. Solitary fibrous tumor of the pleura. Cancer Control 2006;13:264-9. https://doi.org/10.1177/107327480601300403
  10. England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol 1989;13:640-58. https://doi.org/10.1097/00000478-198908000-00003
  11. Moran CA, Suster S, Koss MN. The spectrum of histologic growth patterns in benign and malignant fibrous tumors of the pleura. Semin Diagn Pathol 1992;9:169-80.
  12. Choi YL, Oh YL, Lee MS, Han JH, Ahn GH. Fine needle aspiration cytology of solitary fibrous tumor of the pleura: report of a case misdiagnosed as denocarcinoma of lung. Korean J Cytopathol 2001;12:111-5.
  13. Cardillo G, Facciolo F, Cavazzana AO, Capece G, Gasparri R, Martelli M. Localized (solitary) fibrous tumors of the pleura: an analysis of 55 patients. Ann Thorac Surg 2000;70:1808-12. https://doi.org/10.1016/S0003-4975(00)01908-1
  14. Nonaka M, Kadokura M, Takaba T. Benign solitary fibrous tumor of the parietal pleura which invaded the intercostal muscle. Lung Cancer 2001;31:325-9. https://doi.org/10.1016/S0169-5002(00)00175-6