Radiation Oncology Journal

  • 제26권1호
  • /
  • Pages.10-16
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  • 2008
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  • 2234-1900(pISSN)
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  • 2234-3156(eISSN)
대한방사선종양학회 (The Korean Society for Radiation Oncology)
권호 표지

조기 유방암에서 유방보존치료와 유방절제술 치료성적 비교

A Comparison of Clinical Outcomes for Breast-conserving Treatment and Mastectomy for Early Breast Cancer

  • 노재명 (성균관대학교 의과대학 방사선종양학교실) ;
  • 박원 (성균관대학교 의과대학 방사선종양학교실) ;
  • 허승재 (성균관대학교 의과대학 방사선종양학교실) ;
  • 최두호 (성균관대학교 의과대학 방사선종양학교실) ;
  • 양정현 (성균관대학교 의과대학 외과학교실) ;
  • 남석진 (성균관대학교 의과대학 외과학교실) ;
  • 김정한 (성균관대학교 의과대학 외과학교실) ;
  • 임영혁 (성균관대학교 의과대학 혈액종양내과학교실) ;
  • 안진석 (성균관대학교 의과대학 혈액종양내과학교실)
  • Noh, Jae-Myoung (Departments of Radiation Oncology, Sungkyunkwan University School of Medicine) ;
  • Park, Won (Departments of Radiation Oncology, Sungkyunkwan University School of Medicine) ;
  • Huh, Seung-Jae (Departments of Radiation Oncology, Sungkyunkwan University School of Medicine) ;
  • Choi, Doo-Ho (Departments of Radiation Oncology, Sungkyunkwan University School of Medicine) ;
  • Yang, Jung-Hyun (Departments of Surgery, Sungkyunkwan University School of Medicine) ;
  • Nam, Seok-Jin (Departments of Surgery, Sungkyunkwan University School of Medicine) ;
  • Kim, Jeong-Han (Departments of Surgery, Sungkyunkwan University School of Medicine) ;
  • Im, Young-Hyuck (Departments of Hematology-oncology, Sungkyunkwan University School of Medicine) ;
  • Ahn, Jin-Seok (Departments of Hematology-oncology, Sungkyunkwan University School of Medicine)
  • 발행 : 2008.03.30
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초록

목적: 조기 유방암에서 유방보존치료와 유방절제술의 치료 성적을 비교하고, 예후 인자를 알아보고자 하였다. 대상 및 방법: 1994년 9월부터 2002년 12월까지 본원에서 근치적 수술을 받은 병리학적 병기 $T1{\sim}2N0$ 유방암 환자 1,200명을 후향적으로 분석하여 유방보존치료와 유방절제술을 사이의 차이를 비교해 보았다. 결과: 분석에 포함된 1,174명의 환자 중 601명이(51.2%) 유방보존치료를 받았고 573명이(48.8%) 유방절제술을 받았다. 유방절제술을 받은 군에서 유의하게 종양의 크기가 컸고, 다발성(multicentricity), 에스트로겐 및 프로게스테론 수용체 음성 등의 인자가 더 많은 경향을 보였다. 유방보존치료 및 유방절제술을 받은 환자의 10년 생존율은 각각 91.96%와 91.01%였고(p=0.1274), 10년 무병생존율은 각각 80.48%와 84.95%(p=0.8795)로 유의한 차이를 보이지 않았다. 결론: 조기 유방암에서 유방보존치료 내지는 유방절제술을 받은 군 사이에 환자 특성의 차이는 일부 있었으나 생존율에서 유의한 차이를 보이지 않았다.

Purpose: To compare the treatment outcomes and to analyze prognostic factors between the use of a breast-conserving treatment(BCT) and a mastectomy for early stage breast cancer. Materials and Methods: We retrospectively reviewed 1,200 patients with pathological stage T1-2N0 breast cancer who received surgery between September 1994 and December 2002 at Samsung Medical Center. We compared the patient characteristics and treatment outcomes between the two treatment groups. Results: Among the 1,174 eligible patients, 601(51.2%) patients received a BCT and the remaining 573(48.8%) patients received a mastectomy. The mastectomy group of patients had significantly more cases with a larger tumor size, multicentricity, extensive intraductal component, and estrogen- and progester-one-receptor negativity. The ten-year overall survival rates(OS) of the BCT and mastectomy groups were 91.96% and 91.01%, respectively(p=0.1274). The ten-year disease-free survival rates(DFS) were 80.48% for the BCT group of patients and 84.95% for the mastectomy group of patients, respectively(p=0.8795). Conclusion: Our study shows some differences in patient characteristics between the two treatment groups. However, these differences did not result in significant survival differences.

키워드

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