Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Comparison of Nerve Growth Factor Induction by Butanol Fraction of Liriope platyphylla and Ophiopogon japonicus

산지별 맥문동 부탄올분획물의 신경성장인자 유도 효과에 관한 비교

  • Kang, Tong-Ho (Department of Oriental Pharmaceutical Development, Nambu University) ;
  • Kim, Sun-Yeou (Graduate School of East-West Medical Science, Kyunghee University)
  • 강동호 (남부대학교 한방제약개발학과) ;
  • 김선여 (경희대학교 동서의학대학원)
  • Published : 2008.06.30
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Abstract

Nerve growth factor (NGF) is a protein plays a major role in the development and maintenance of central and peripheral nervous system. Recent data suggest that reduced availability of NGF may play a significant role in the pathogenesis of diabetic $polyneuropathy.^{1)}$ In our previous study, steroidal saponin from Liriope platyphylla showed neurotrophic effect by stimulation of NGF synthesis and activation of tyrosine kinase $signaling.^{2)}$ In this study, we examined the neurotrophic effect of Liriope platyphylla (LP); which was from Mylyang(MYL) and Cheongyang(CHE), and Ophiopogon japonicus (CHI) on in vitro and in vivo model for the comparison of their NGF induction. We quantitatively analyzed spicatoside A in the LP and CHI by HPLC. And we investigated the correlation between the contents of spicatoside A and NGF induction efficacy on PC 12 cells and mouse serum. These results suggest that spicatoside A may enhance NGF induction in animal model.

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References

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