Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of ChenwhangBosim-Dan and SungsimJihwang-Tang on Protecting Microglia and Inhibiting Acetylcholinesterase and Oxidants

천왕보심단(天王補心丹)과 성심지황탕(醒心地黃湯)의 microglia 보호, 항산화 및 acetylcholinesterase 억제 효과

  • Jung, In-Chul (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
  • 정인철 (대전대학교 한의과대학 신경정신과학교실)
  • Published : 2008.02.25
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Abstract

This experiment was designed to investigate the effect of the CBD and SJT extract on protecting microglia and inhibiting acetylcholinesterase and oxidants. The effects of the CBD and SJT extract on cell death of BV2 microglial cell line treated by $IFN-{\gamma}$ ; expression of NO, ROS in BV2 microglial cell line treated by lipopolysaccharide(LPS) ; AChE activity in PC-12 cell treated by NGF were investigated, respectively. The CBD and SJT extract significantly increased cell viability in BV2 microglial cell line treated with $IFN-{\gamma}$. The CBD and SJT extract suppressed the NO and ROS production in BV2 microglial cell line treated by LPS. The CBD and SJT extract groups also showed inhibition of AChE activity in PC-12 cell line. According to the above result, it is suggested that the CBD and SJT extract might be usefully applied for prevention and treatment of Alzheimer's disease.

Keywords

References

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