Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Study on the Protective Effect of Corni Fructus Against Free Radical Mediated Liver Damage

산수유의 유리자유기에 의한 간손상 보호효과 및 기전에 대한 연구

  • Ha, Ki-Tae (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Kim, Young-Mi (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Kim, Cheorl-Ho (Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University) ;
  • Choi, Dall-Yeong (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Kim, June-Ki (Department of Pathology, College of Oriental Medicine, Dongguk University)
  • 하기태 (동국대학교 한의과대학 병리학교실) ;
  • 김영미 (동국대학교 한의과대학 병리학교실) ;
  • 김철호 (성균관대학교 자연과학부 생명과학과) ;
  • 최달영 (동국대학교 한의과대학 병리학교실) ;
  • 김준기 (동국대학교 한의과대학 병리학교실)
  • Published : 2008.02.25
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Abstract

We evaluated the potential protective activity of the traditional Korean medicinal herb, Corni fructus (CF), in an experimental model of hepatotoxicity induced by carbontetrachloride $(CCl_4)$. The CF exhibited a hepatoprotective activity against Chang cell. And The expression of cytochrome P450 2E1 (CYP2E1), measured by RT-PCR and western blot, was significantly decreased in the CF treated Chang cell. But $CCl_4$ and CF has no significant effect on 1A1 and 3A1 isoform of cytochrome P450. Based on these findings, it is suggested that hepatoprotective effects of CF possibly related to antioxidative effects and downregulation of CYP2E1 expression.

Keywords

References

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