Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Immune-modulator Effect of Zanthoxyli Pericarpium Watet Extract

천초 추출물의 면역 조절 효과

  • Shin, Hye-Young (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Department of Oriental Medicine, Wonkwang University) ;
  • Chang, In-Ae (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Department of Oriental Medicine, Wonkwang University) ;
  • Zhang, Wen-Ji (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Department of Oriental Medicine, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University School of Medicine) ;
  • Yun, Yong-Gab (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Department of Oriental Medicine, Wonkwang University) ;
  • Park, Hyun (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine)
  • 신혜영 (원광대학교 인수공통, 감염병 연구센터 및 의과대학 감염생물학교실, 한의과대학 방제학교실) ;
  • 장인애 (원광대학교 인수공통, 감염병 연구센터 및 의과대학 감염생물학교실, 한의과대학 방제학교실) ;
  • 장문희 (원광대학교 인수공통, 감염병 연구센터 및 의과대학 감염생물학교실, 한의과대학 방제학교실) ;
  • 김윤철 (약학대학) ;
  • 윤용갑 (원광대학교 인수공통, 감염병 연구센터 및 의과대학 감염생물학교실, 한의과대학 방제학교실) ;
  • 박현 (원광대학교 인수공통, 감염병 연구센터 및 의과대학 감염생물학교실)
  • Published : 2008.04.25
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Abstract

In the recently, increased concern has been focused on the pharmacology and clinical utility of herbal extracts and derivatives as a drug or adjunct to chemotherapy and immunotherapy. Here we investigated the modulatory effects of the extract of Zanthoxyli Pericarpium (ZP) in production of inflammatory mediators from Raw264.7 cells and expression of CD86, CD14, toll-like receptor (TLR)-4 from peritoneal macrophage. ZP enhanced the production of NO and $TNF-{\alpha}$ as well as mRNA expression of iNOS and $TNF-{\alpha}$. Treatment of peritoneal macrophage with ZP resulted in the enhanced cell-surface molecules expression of CD86, CD14 and TLR4. We assayed the effect of ZP in cell proliferation and production of $IFN-{\gamma},\;TNF-{\alpha}$. ZP increased Con A-induced cell proliferation and production of $IFN-{\gamma},\;TNF-{\alpha}$. These studies indicate that ZP induces macrophage activation and suggest the possible use of ZP in macrophage-based immunotherapies

Keywords

References

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