한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제16권2호
  • /
  • Pages.100-105
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  • 2008
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
권호 표지

한약재인 황금의 궤양성 실험동물에 대한 장간막 임파절 임파구의 면역글로블린 수준, T세포집단, 사이토카인 생성의 조절작용

Scutellaria baicalensis Modulates Cytokine Production, T Cell Population and Immunoglobulin Level by Mesenteric Lymph Node Lymphocytes in Experimental Mice with Colitis

  • 임병우 (건국대학교 의료생명대학 생명과학부) ;
  • 박표잠 (건국대학교 의료생명대학 생명과학부) ;
  • 최완수 (건국대학교 의학전문대학원 면역학 교실) ;
  • 김종대 (강원대학교 BT특성화 대학)
  • Lim, Beong-Ou (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Park, Pyo-Jam (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Choi, Wahn-Soo (College of Medicine, Konkuk University) ;
  • Kim, Jong-Dai (School of Biotechnology and Bioengineering, Kangwon National University)
  • 발행 : 2008.04.30
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초록

We previously examined extracts, isolated from Scutellaria baicalensis (SB), chemical mediators, and IgE by mesenteric lymph node (MLN) lymphocytes in rats. The present study was to evaluate the effects of extracts of SB on the MLN lymphocytes function of mice given orally by 20 mg/kg for 2 weeks with dextran sulfate sodium (DS)-induced colitis. Results show that IgE levels in MLN lymphocytes was low, while IgA was high, in mice given SB compared to that fed water. Concentrations of $Inteferon-{\gamma}$ and interleukin (IL)-2 of T cells by concanavalin A treatment was significantly higher in the SB fed group than the normal group. Activation-induced IL-4 and IL-10 secretion was lower in SB fed mice compared control mice after DS-induced colitis. These results suggested that SB suppresses the inflammation in DS-induced colitis through the modulation of Th1/Th2 balance to down-regulate $Th_2$ response in MLN lymphocytes.

키워드

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