Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antithrombotic Compounds form the Leaves of Ligularia stenocephala M.

  • Yoon, Min-Ho (Department of Bio Environmental Chemistry, College of Agriculture, Chungnam National University) ;
  • Cho, Chong-Woon (Department of Bio Environmental Chemistry, College of Agriculture, Chungnam National University) ;
  • Lee, Jae-Won (Department of Bio Environmental Chemistry, College of Agriculture, Chungnam National University) ;
  • Kim, Young-Shin (Department of Bio Environmental Chemistry, College of Agriculture, Chungnam National University) ;
  • An, Gil-Hwan (Department of Food Science and Technology, College of Agriculture, Chungnam National University) ;
  • Lim, Chi-Hwan (Department of Bio Environmental Chemistry, College of Agriculture, Chungnam National University)
  • Published : 2008.03.31
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Abstract

The leaf extract of Ligularia stenocephala showed the highest anti-platelet aggregating activity in large numbers of edible and herbal plants. The active fraction fractionationed from L. stenocephala extract by using preparative HPLC inhibited the platelet aggregation up to above 80% and its blood coagulating time (PT and APTT) also showed similar effect to aspirin (0.2 ${\mu}g/mL$), known as an anti-thrombus compound. Two antithrombus active compounds were purified and identified as 3,5-dicaffeoylquinic acid and 3,4-dicaffeoylquinic acid, respectively, on the basis of NMR and FAB-MS spectroscopic data. Two active compounds has not only antiplatelet aggregating activity, but also has anticoagulating activity.

Keywords

References

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