YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Modulation of Th1/Th2 Cytokine Secretion in Human Peripheral Blood Mononuclear Cells by Water Extract of Acanthopanax divaricatus var. albeofructus Fruits

사람 말초혈액 단핵세포에서 흰털오가피 열매 추출물에 의한 Th1/Th2 Cytokine 분비조절

  • Lyu, Su-Yun (College of Natural Sciences, Seoul Women's University) ;
  • Noh, Bin-Na (College of Natural Sciences, Seoul Women's University) ;
  • Park, Won-Bong (College of Natural Sciences, Seoul Women's University)
  • 유수연 (서울여자대학교 자연과학대학) ;
  • 노빛나 (서울여자대학교 자연과학대학) ;
  • 박원봉 (서울여자대학교 자연과학대학)
  • Published : 2008.02.29
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Abstract

Water extracts of Acanthopanax divaricatus var. albeofructus (ADA) fruits were used to treat hPBMC to determine the mechanisms for the immunomodulatory effects. The secretion level of various cytokines including Th-1 type (IL-2, L-12, $IFN-{\gamma}$ and $TNF-{\alpha}$) and Th-2 type (IL-6, IL-8 and IL-10) were measured using ELISA. A significant increase of Th-1 type cytokine secretion was observed in the presence of extract while Th-2 cytokine, IL-6 was suppressed. Our results suggest that ADA fruit extract may influence the anticancer immune responses towards a predominance of Th-1 cytokines in the immune system.

Keywords

References

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