Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Association between Endometriosis and Human ${\alpha}2$-Heremans Schmidt Glycoprotein (AHSG) Polymorphism

한국 여성에서 중증 자궁내막증과 Human ${\alpha}2$-Heremans Schmidt Glycoprotein (AHSG) 유전자 다형성의 연관성

  • Kim, Jin-Ju (Department of Obstetrics and Gynecology, Seoul National University College of Medicine) ;
  • Chae, Soo-Jin (Department of Obstetrics and Gynecology, Maria Fertility Hospital) ;
  • Kim, Jong-Mee (Department of Obstetrics and Gynecology, Seoul National University College of Medicine) ;
  • Lee, Gyoung-Hoon (Department of Obstetrics and Gynecology, Gachon University Gil Medical Center) ;
  • Choi, Young-Min (Department of Obstetrics and Gynecology, Seoul National University College of Medicine) ;
  • Kim, Sung-Hoon (Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center) ;
  • Shin, Jung-Ho (Department of Obstetrics and Gynecology, Korea University College of Medicine) ;
  • Lee, Taek-Hoo (Department of Obstetrics and Gynecology, Kyungpook National University School of Medicine) ;
  • Hur, Jun-Young (Department of Obstetrics and Gynecology, Korea University College of Medicine) ;
  • Lee, Byoung-Suk (Department of Obstetrics and Gynecology, Yonsei University College of Medicine) ;
  • Oh, Sung-Tack (Department of Obstetrics and Gynecology, Chonnam National University College of Medicine) ;
  • Lee, Kyu-Sup (Department of Obstetrics and Gynecology, Pusan National University College of Medicine and Medical Research Institute, Pusan National University) ;
  • Lim, Young-Tack (Department of Obstetrics and Gynecology, St Vincent's Hospital, College of Medicine, Catholic University of Korea)
  • 김진주 (서울대학교 의과대학 산부인과학교실) ;
  • 채수진 (서울마리아 불임병원) ;
  • 김종미 (서울대학교 의과대학 산부인과학교실) ;
  • 이경훈 (가천의과학대학교 산부인과학교실) ;
  • 최영민 (서울대학교 의과대학 산부인과학교실) ;
  • 김성훈 (울산대학교 의과대학 산부인과학교실) ;
  • 신정호 (고려대학교 의과대학 산부인과학교실) ;
  • 이택후 (경북대학교 의과대학 산부인과학교실) ;
  • 허준용 (고려대학교 의과대학 산부인과학교실) ;
  • 이병석 (연세대학교 의과대학 산부인과학교실) ;
  • 오성택 (전남대학교 의과대학 산부인과학교실) ;
  • 이규섭 (부산대학교 의과대학 산부인과학교실) ;
  • 임용택 (가톨릭대학교 의과대학 산부인과학교실)
  • Published : 2008.12.30
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Abstract

Objective: To evaluate the relationship between advanced stage endometriosis and polymorphisms in $\alpha$2-Heremans Schmidt glycoprotein (AHSG) gene in Korean women. Methods: One-hundred thirty women with endometriosis stage III and IV, and 224 women without endometriosis were enrolled. In these patients, we determined AHSG gene polymorphisms by PCR and RFLP (restriction fragment length polymorphism) analysis. Results: The genotype distribution of the AHSG gene polymorphism in the endometriosis group was not different from that of the control group (AHSG 1*1/AHSG 1*2/AHSG 2*2 frequencies were 56.2%/37.7%/6.2% and 55.8%/39.3%/4.9% for the endometriosis and control groups, respectively, p=.864). Also, the frequency of AHSG 2 haplotype was not different between endometriosis patients and controls (AHSG 1 haplotype /AHSG 2 haplotype rates were 75.0%/25.0% and 75.4%/24.6% for the endometriosis and control groups, respectively, p=0.894). Conclusion: AHSG gene polymorphism was not associated with the risk of advanced stage endometriosis in the Korean population.

목 적: 한국 여성에서 alpha2-Heremans Schmidt glycoprotein (AHSG) 유전자 다형성과 중증 자궁내막증의 연관성을 알아보고자 하였다. 연구방법: 자궁내막증이 없는 여성 224명과 중증 자궁내막증이 있는 여성 130명을 대상으로 하였다. 모든 여성은 복강경이나 개복수술을 시행하여 수술 소견 및 조직학적 진단으로 중증 자궁내막증의 존재 여부를 진단하였다. 환자군과 대조군의 혈액을 채취하였고 AHSG 유전자 다형성을 중합효소연쇄반응 (PCR) 및 제한효소 절편길이 다형성(restriction fragment length polymorphism; RFLP) 분석으로 조사하였다. 결 과: 자궁내막증 환자군에서 AHSG 1*1 유전자형의 빈도는 56.2% (73/130), AHSG 1*2 유전자형은 37.7% (49/130), AHSG 2*2 유전자형은 6.2% (8/130)로 정상 대조군의 55.8% (125/224), 39.3% (88/224), 4.9% (11/224)의 빈도와 차이가 없었다 (p=.864). 또한 AHSG 2 일배체형의 빈도 역시 환자군에서 25.0% (65/260), 대조군 24.6% (110/448)로 두 군간에 유의한 차이가 없었다 (p=.894). 결 론: 한국 여성에서 AHSG 유전자 다형성과 자궁내막증은 연관이 없었다.

Keywords

References

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