Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
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티타늄 금속나노입자의 혈액응고작용 검색

Screening Test of Titanium Dioxide Nanoparticles on Blood Coagulation and Platelet Aggregation

  • 박광식 (동덕여자대학교 약학대학)
  • 발행 : 2008.12.30
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초록

Effects of titanium dioxide nanoparticles on blood coagulation and platelet aggregation were investigated using diluted whole blood and platelet rich plasma (PRP) solution prepared from human and rat blood, respectively. Blood coagulation was monitored by using a whole blood impedance aggregometer and titanium dioxide nanoparticle (10, 20, and 40 ppm) did not show any effect on the coagulation both in human and in rat blood. When platelet aggregation was measured by turbidometric method after addition of titanium dioxide nanoparticles to PRP solution with final concentrations of 1, 5 and 10 ppm. no aggregation was observed.

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참고문헌

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