Acknowledgement
Supported by : Korea Research Foundation, Korea Science and Engineering Foundation
References
- Akira, S. (2003). Mammalian Toll-like receptors. Curr. Opin. Immunol. 15, 5-11 https://doi.org/10.1016/S0952-7915(02)00013-4
- Blennow, K., Davidsson, P., Wallin, A., Fredman, P., Gottfries, C.G., Karlsson, I., Mansson, J.E., and Svennerholm, L. (1991). Gangliosides in cerebrospinal fluid in 'probable Alzheimer's disease'. Arch. Neurol. 48, 1032-1035 https://doi.org/10.1001/archneur.1991.00530220048018
- Derry, D.M. and Wolfe, L.S. (1967). Gangliosides in isolated neurons and glial cells. Science 158, 1450-1452 https://doi.org/10.1126/science.158.3807.1450
- Dreyfus, H., Guerold, B., Freysz, L., and Hicks, D. (1997). Successive isolation and separation of the major lipid fractions including gangliosides from single biological samples. Anal. Biochem. 249, 67-78 https://doi.org/10.1006/abio.1997.2143
- Dustin, M.L. (2002). Membrane domains and the immunological synapse: keeping T cells resting and ready. J. Clin. Invest. 109, 155-160
- Gisslen, M., Hagberg, L., Norkrans, G., Lekman, A., and Fredman, P. (1997). Increased cerebrospinal fluid ganglioside GM1 concentrations indicating neuronal involvement in all stages of HIV-1 infection. J. Neurovirol. 3, 148-152 https://doi.org/10.3109/13550289709015804
- Jou, I., Lee, J.H., Park, S.Y., Yoon, H.J., Joe, E.H., and Park, E.J. (2006). Gangliosides trigger inflammatory responses via TLR4 in brain glia. Am. J. Pathol. 168, 1619-1630 https://doi.org/10.2353/ajpath.2006.050924
- Kaisho, T. and Akira, S. (2006). Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 117, 979-987 https://doi.org/10.1016/j.jaci.2006.02.023
- Kawai, T. and Akira, S. (2007). TLR signaling. Semin. Immunol. 19, 24-32
- Kim, O.S., Park, E.J., Joe, E.H., and Jou, I. (2002). JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells. J. Biol. Chem. 277, 40594-40601 https://doi.org/10.1074/jbc.M203885200
- Ledesma, M.D., Da Silva, J.S., Crassaerts, K., Delacourte, A., De Strooper, B., and Dotti, C.G. (2000). Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains. EMBO Rep. 1, 530-535
- Lee, M.S. and Kim, Y.J. (2007). Pattern-recognition receptor signaling initiated from extracellular, membrane, and cytoplasmic space. Mol. Cells 23, 1-10
- Lee, J.H., Park, E.J., Kim, O.S., Kim, H.Y., Joe, E.H., and Jou, I. (2005). Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells. Glia 50, 66-79 https://doi.org/10.1002/glia.20156
- McLaurin, J., Franklin, T., Fraser, P.E., and Chakrabartty, A. (1998). Structural transitions associated with the interaction of Alzheimer beta-amyloid peptides with gangliosides. J. Biol. Chem. 273, 4506-4515 https://doi.org/10.1074/jbc.273.8.4506
- Medzhitov, R., Preston-Hurlburt, P., and Janeway, C.A., Jr. (1997). A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394-397 https://doi.org/10.1038/41131
- Michikawa, M., Gong, J.S., Fan, Q.W., Sawamura, N., and Yanagisawa, K. (2001). A novel action of alzheimer's amyloid betaprotein (Abeta): oligomeric Abeta promotes lipid release. J. Neurosci. 21, 7226-7235
- Miyake, K. (2007). Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin. Immunol. 19, 3-10
- O'Neill, L.A. (2002). Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily. Curr. Top Microbiol. Immunol. 270, 47-61
- Rajendran, L. and Simons, K. (2005). Lipid rafts and membrane dynamics. J. Cell Sci. 118, 1099-1102 https://doi.org/10.1242/jcs.01681
- Sabroe, I., Read, R.C., Whyte, M.K., Dockrell, D.H., Vogel, S.N., and Dower, S.K. (2003). Toll-like receptors in health and disease: complex questions remain. J. Immunol. 171, 1630-1635
- Sonnino, S. and Chigorno, V. (2000). Ganglioside molecular species containing C18- and C20-sphingosine in mammalian nervous tissues and neuronal cell cultures. Biochim. Biophys. Acta 1469, 63-77 https://doi.org/10.1016/S0005-2736(00)00210-8
- Soong, G., Reddy, B., Sokol, S., Adamo, R., and Prince, A. (2004). TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cells. J. Clin. Invest. 113, 1482-1489
- Triantafilou, M., Miyake, K., Golenbock, D.T., and Triantafilou, K. (2002). Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharideinduced cell activation. J. Cell Sci. 115, 2603-2611
- Ulevitch, R. J. (2004). Therapeutics targeting the innate immune system. Nat. Rev. Immunol. 4, 512-520 https://doi.org/10.1038/nri1396
- Wang, S.S., Rymer, D.L., and Good, T.A. (2001). Reduction in cholesterol and sialic acid content protects cells from the toxic effects of beta-amyloid peptides. J. Biol. Chem. 276, 42027-42034 https://doi.org/10.1074/jbc.M102834200
- Yanagisawa, K., Odaka, A., Suzuki, N., and Ihara, Y. (1995). GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease. Nat. Med. 1, 1062-1066 https://doi.org/10.1038/nm1095-1062
- Yang, M.S., Park, E.J., Sohn, S., Kwon, H.J., Shin, W.H., Pyo, H.K., Jin, B., Choi, K.S., Jou, I., and Joe, E.H. (2002). Interleukin- 13 and -4 induce death of activated microglia. Glia 38, 273-280 https://doi.org/10.1002/glia.10057