Journal of fish pathology (한국어병학회지)

The Korean Society of Fish Pathology (한국어병학회)
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Pharmacokinetics of Oral Administration of Oxytetracycline in Eel, Anguilla japonica

Oxytetracycline의 경구 투여에 따른 뱀장어 체내 약물동태학적 특성

  • 김진도 (국립수산과학원 남부내수면연구소) ;
  • 서정수 (국립수산과학원 병리연구팀) ;
  • 김주완 (국립수산과학원 병리연구팀) ;
  • 이주석 (강릉대학교) ;
  • 정승희 (국립수산과학원 병리연구팀) ;
  • 지보영 (국립수산과학원 병리연구팀) ;
  • 김진우 (국립수산과학원 병리연구팀) ;
  • 김응오 (남해수산연구소 증식팀)
  • Published : 20080800
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Abstract

Oxytetracycline (OTC) has been widely used in eel culture as a therapeutic and prophylactic agent because of its broad-spectrum activity against gram-positive and -negative bacteria. The oral treatment dosage of OTC approved for the treatment of edwardsiellosis, furunculosis and vibriosis in eel is 50 mg/kg/day for 3-7 days in Korea. To determine new optimum dose of OTC in eel, the pharmacokinetics of OTC after single oral administration (100 mg/kg B.W., 200 mg/kg B.W.) in cultured eel, Anguilla japonica was examined. In oral dosage of 100 and 200 mg/kg body weight, the highest plasma concentrations of OTC were 1.19±0.42 ㎍/㎖ and 2.69±0.57 ㎍/㎖, respectively. Plasma concentrations of OTC were not detected after 720 h post-dose in all experiments. The kinetic profile of absorption, distribution and elimination of OTC in plasma wwas calculated fitting to a 1- and 2-compartment model by WinNonlin program. The following parameters were obtained for a single dosage of 100 and 200 mg/kg respectively: 1-compartment model, AUC= 82.48 and 432.68 ㎍*h/㎖, Tmax= 3.93 and 14.24 hr, Cmax= 0.94 and 2.34 ㎕/㎖; 2-compartment model, AUC= 448.73 and 530.65 ㎍*h/㎖, Tmax= 6.37 and 8.96 hr, Cmax= 0.90 and 3.21 ㎕/㎖.

Keywords

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