Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Medical imaging and immunohistochemical diagnosis of gastrointestinal stromal tumor originated from colon in a dog

개의 결장 간질종양에 대한 영상의학 및 면역조직화학 진단 1예

  • Choi, Jihye (Haemaru Referral Animal Hospital) ;
  • Kim, Hyunwook (Haemaru Referral Animal Hospital) ;
  • Lee, Haekyung (Haemaru Referral Animal Hospital) ;
  • Kim, Junyoung (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Yoon, Junghee (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University)
  • 최지혜 (해마루 이차진료동물병원) ;
  • 김현욱 (해마루 이차진료동물병원) ;
  • 이혜경 (해마루 이차진료동물병원) ;
  • 김준영 (서울대학교 수의과대학 BK21 수의과학연구인력양성사업단) ;
  • 윤정희 (서울대학교 수의과대학 BK21 수의과학연구인력양성사업단)
  • Accepted : 2008.01.17
  • Published : 2008.03.30
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Abstract

Gastrointestinal stromal tumor (GIST) is one of the mesenchymal tumors originated from gastrointestinal submucosa. A 10 year-old, male, mixed breed dog with persistent diarrhea, anorexia and lethargy was referred to Haemaru Animal Referral Hospital. Large mass originated from the transverse colon was observed and large amount of ascites and free gas were found on abdominal radiography and ultrasonography. The ascites was septic exudate mixed with bacteria that consisted with intestinal perforation. There was no metastatic lesion. This mass was tentatively diagnosed as adenocarcinoma, leiomyosarcoma (LMS) and lymphosarcoma and surgical resection and histilogical examination were planned. However, according to owner's request, the patient was euthanized and then the necropsy was performed. About 10 cm sized mass originated from the cecum, ascending colon and transverse colon was adhered to surrounding mesentery and the perforation and large amount of ascites were observed. GIST was suspected on histopathologic examination and confirmed according to CD 117 expression in immunohistochemistry. GIST, derived from interstitial cells of Cajal, can be distinguished from LMS and leiomyoma (LM) on the basis of expression of CD117 (KIT) immunohistochemically. GIST has a different biological behavior and clinical course compared with LMS and LM, therefore definite diagnosis for GIST using immunohistochemistry is clinically important to predict the precise prognosis of the patient.

Keywords

References

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