Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
권호 표지
DOI QR코드

DOI QR Code

Biological Effectiveness of Methionine Hydroxy-analogue Calcium Salt in Relation to DL-Methionine in Broiler Chickens

  • Elwert, C. (Feedtest, Gottgau 3b) ;
  • de Fernandes, E. Abreu (UFU) ;
  • Lemme, A. (Evonik Degussa GmbH)
  • Received : 2008.04.10
  • Accepted : 2008.06.21
  • Published : 2008.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Two feeding trials were conducted to assess the relative bioavailability (RBV) of methionine hydroxy analogue calcium salt (MHA-Ca) in comparison to DL-methionine (DL-Met). Male Ross 308 (1-38 days) and Cobb 500 chickens (1-42 days) were used in studies 1 and 2, respectively. Experimental diets based on wheat and soybean meal or sorghum and soybean meal were fed during three phases. In both experiments graded levels of DL-Met and MHA-Ca were supplemented to Met+Cys deficient basal diets. Additionally, in experiment 1, increasing levels of a DL-Met preparation diluted with corn starch to 65% purity (DL-Met65) were supplemented. Birds were kept in floor pens and feed and water were available ad libitum. Body weights and feed consumption were recorded at the beginning and end of the experimental periods and weight gain and feed efficacy were computed subsequently. At the end of the experiments, a number of birds were slaughtered for carcass evaluation (dressing percentage, breast meat yield). Dose response data were analysed by both ANOVA and nonlinear common plateau asymptotic regression. In both experiments birds responded significantly to increasing levels of either methionine source. However, RBV of MHA-Ca compared to DL-Met was markedly (in many cases significantly) below 84%, the value which would have been expected from MHA-Ca's chemical characteristics. Excluding some extremely low RBV figures of trial 2, RBV of MHA-Ca averaged to about 63% in relation to DL-Met. In addition, supplementation of DL-Met65 allowed confirmation of nonlinear common plateau asymptotic regression to be suitable to determine RBV.

Keywords

References

  1. Drew, M. D., A. G. van Kessel and D. D. Maenz. 2003. Absorption of methionine and 2-hydroxy-4-methylthiobutanoic acid in conventional and germ-free chickens. Poult. Sci. 82:1149-1153. https://doi.org/10.1093/ps/82.7.1149
  2. Esteve-Garcia, E. 1988. Digestion and excretion of methionine sources for poultry. PhD thesis, Cornell University, Ithaca, New York, USA.
  3. Esteve-Garcia, E. and R. E. Austic. 1993. Intestinal absorption and renal excretion of dietary methionine sources by the growing chicken. J. Nutr. Biochem. 4:576-587. https://doi.org/10.1016/0955-2863(93)90026-S
  4. Hoehler, D. 2006. Letter to the editor: No evidence for different dose responses of commercial methionine sources in broilers. Poult. Sci. 85:2047. https://doi.org/10.1093/ps/85.12.2047
  5. Hoehler, D. 2007. Letter to the editor (Letter): A misleading approach to determine the methionine activity of organic trace minerals. Poult. Sci. 86:1611-1612. https://doi.org/10.1093/ps/86.8.1611
  6. Jansman, A. J. M., C. A. Kan and J. Wiebenga. 2003. Comparison of the biological efficacy of DL-methionine and hydroxy-4- methylthiobutanoic acid (HMB) in pigs and poultry. CVB documentation report Nr. 29, Centraal Veevoederbureau, Lelystad, The Netherlands.
  7. Kratzer, D. D. and R. C. Littell. 2006. Appropriate statistical methods to compare dose responses of methionine sources. Poult. Sci. 85:947-954. https://doi.org/10.1093/ps/85.5.947
  8. Lemme, A., D. Hoehler, J. J. Brennan and P. F. Mannion. 2002. Relative effectiveness of methionine hydroxy analog compared to DL-methionine in broiler chickens. Poult. Sci. 81:838-845. https://doi.org/10.1093/ps/81.6.838
  9. Lemme, A. and A. Petri. 2003. The effectiveness of liquid methionine hydroxy analogue relative to DL-methionine - A literature review. AminoNewsTM 4(3):1-10.
  10. Lemme, A. 2004. Relative effectiveness of the methionine hydroxy analogue calcium salt in broilers and layers. AminoNewsTM 5(3):7-12.
  11. Lingens, G. and S. Molnar. 1996. Studies on metabolism of broilers by using 14C-labelled DL-Methionine and DLMethionine hydroxy analogue Ca-salt. Arch. Anim. Nutr. 49:113-124. https://doi.org/10.1080/17450399609381871
  12. Littell, R. A., P. R. Henry, A. J. Lewis and C. B. Ammermann. 1997. Estimation of relative bioavailability of nutrients using SAS procedures. J. Anim. Sci. 75:2672-2683. https://doi.org/10.2527/1997.75102672x
  13. Mandal, A. B., A. V. Elangovan and T. S. Johri. 2004. Comparing bio-efficacy of liquid DL-methionine hydroxy analogue free acid with DL-methionine in broiler chickens. Asian-Aust. J. Anim. Sci. 17:102-108. https://doi.org/10.5713/ajas.2004.102
  14. Piepho, H.-P. 2006. Letter to the editor: A cautionary note on appropriate statistical methods to compare dose responses of methionine sources. Poult. Sci. 85:1511-1512.
  15. Potter, L. M., G. P. Schmidt, M. E. Blair, J. R. Shelton and B. A. Bliss. 1984. MHAC versus DL-methionine-Part I: The methionine controversy. Animal Nutrition and Health (March- April):14-17.
  16. Richards, J. D., J. J. Dibner and C. D. Knight. 2007. Letters to the editor (Reply): DL-2-hydroxy-4-(methylthio)butanoic acid from any commercial source is fully available as a source of methionine activity. Poult. Sci. 86:1613-1614. https://doi.org/10.1093/ps/86.8.1613
  17. SAS Institute. 2004. SAS/STAT User's Guide. Release 9.1. SAS Institute Inc., Cary, NC.
  18. Sauer, N., K. Emrich, H. P. Piepho, A. Lemme, M. S. Redshaw and R. Mosenthin. 2007. Meta-analysis on the relative efficiency of methionine-hydroxy-analogue-free-acid compared with DL-methionine in broilers using non-linear mixed models. Poult. Sci. (In press). (partly published in: Sauer, N., K. Emrich, H. P. Piepho, A. Lemme, M. S. Redshaw and R. Mosenthin. 2007. Meta-analysis on the relative efficiency of the liquid hydroxy analogue compared with DL-methionine in broilers using multi-exponential regression. 16th European Symposium on Poultry Nutrition, August 27-30, Strasbourg, France: 4).
  19. Vazquez-Anon, M., D. Kratzer, R. Gonzelez-Esquerra, I. G. Yi and C. D. Knight. 2006. A multiple regression model approach to contrast the performance of 2-hydroxy-4-methylthio butanoic acid and DL-methionine supplementation tested in broiler experiments and reported in the literature. Poult. Sci. 85:693- 705. https://doi.org/10.1093/ps/85.4.693
  20. Yi, G. F., C. A. Atwell, J. A. Hume, J. J. Dibner, C. D. Knight and J. D. Richards. 2007. Determining the methionine activity of Mintrex organic trace minerals in broiler chicks by using radiolabel tracing or growth assay. Poult. Sci. 86:877-887. https://doi.org/10.1093/ps/86.5.877

Cited by

  1. Bioavailability of different methionine sources for growing broilers vol.43, pp.3, 2014, https://doi.org/10.1590/S1516-35982014000300006
  2. 2-Hydroxy-4-methylthio butanoic acid and DL-methionine for Japanese quails in production pp.09312439, 2017, https://doi.org/10.1111/jpn.12813
  3. Relative Bioavailability of DL and L-Methionine in Broilers vol.08, pp.02, 2018, https://doi.org/10.4236/ojas.2018.82011
  4. Assessment of Meat Quality and Shelf Life from Broilers Fed with Different Sources and Concentrations of Methionine vol.2019, pp.1745-4557, 2019, https://doi.org/10.1155/2019/6182580
  5. Physiological and biochemical aspects of methionine isomers and a methionine analogue in broilers vol.96, pp.2, 2008, https://doi.org/10.3382/ps/pew253
  6. Gene expression and activity of methionine converting enzymes in broiler chickens fed methionine isomers or precursors vol.97, pp.6, 2008, https://doi.org/10.3382/ps/pey037
  7. Effects of different methionine sources on growth performance, meat yield and blood characteristics in broiler chickens vol.47, pp.1, 2008, https://doi.org/10.1080/09712119.2019.1617719
  8. Effects of dietary methionine supplementation on growth performance, intestinal morphology, antioxidant capacity and immune function in intra‐uterine growth‐retarded suckling piglets vol.103, pp.3, 2019, https://doi.org/10.1111/jpn.13084
  9. Supplemental methionine exerted chemical form-dependent effects on antioxidant status, inflammation-related gene expression, and fatty acid profiles of broiler chicks raised at high ambient temperatur vol.97, pp.12, 2008, https://doi.org/10.1093/jas/skz348
  10. Letter to the editor vol.76, pp.1, 2020, https://doi.org/10.1080/00439339.2020.1713442
  11. Utilization of Methionine Sources for Growth and Met+Cys Deposition in Broilers vol.10, pp.12, 2008, https://doi.org/10.3390/ani10122240