Acknowledgement
Supported by : Ministry of Science and Technology
References
- Amsellem, S., Pflumio, F., Bardinet, D., Izac, B., Charneau, P., Romeo, P.H., Dubart-Kupperschmitt, A., and Fichelson, S. (2003). Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein. Nat. Med. 9, 1423-1427 https://doi.org/10.1038/nm953
- Bowles, K.M., Vallier, L., Smith, J.R., Alexander, M.R., and Pedersen, R.A. (2006). HOXB4 overexpression promotes hematopoietic development by human embryonic stem cells. Stem Cells 24, 1359-1369 https://doi.org/10.1634/stemcells.2005-0210
- Brun, A.C., Fan, X., Bjornsson, J.M., Humphries, R.K., and Karlsson, S. (2003). Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood CD34+ cells promotes myeloid differentiation but not proliferation. Mol. Ther. 8, 618-628 https://doi.org/10.1016/S1525-0016(03)00237-5
- Chadwick, K., Wang, L., Li, L., Menendez, P., Murdoch, B., Rouleau, A., and Bhatia, M. (2003). Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood 102, 906-915 https://doi.org/10.1182/blood-2003-03-0832
- Giampaolo, A., Sterpetti, P., Bulgarini, D., Samoggia, P., Pelosi, E., Valtieri, M., and Peschle, C. (1994). Key functional role and lineage-specific expression of selected HOXB genes in purified hematopoietic progenitor differentiation. Blood 84, 3637-3647
- Ishikawa, F., Yasukawa, M., Lyons, B., Yoshida, S., Miyamoto, T., Yoshimoto, G., Watanabe, T., Akashi, K., Shultz, L.D., and Harada, M. (2005). Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain (null) mice. Blood 106, 1565-1573 https://doi.org/10.1182/blood-2005-02-0516
- Ito, M., Hiramatsu, H., Kobayashi, K., Suzue, K., Kawahata, M., Hioki, K., Ueyama, Y., Koyanagi, Y., Sugamura, K., Tsuji, K., et al. (2002). NOD/SCID/gamma(c) (null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100, 3175-3182 https://doi.org/10.1182/blood-2001-12-0207
- Kaufman, D.S., Hanson, E.T., Lewis, R.L., Auerbach, R., and Thomson, J.A. (2001). Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc. Natl. Acad. Sci. USA 98, 10716-10721
- Keller, G. (2005). Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev. 19, 1129-1155 https://doi.org/10.1101/gad.1303605
- Kim, S.E., Kim, B.K., Gil, J.E., Kim, S.K., and Kim, J.H. (2007). Comparative analysis of the developmental competence of three human embryonic stem cell lines in vitro. Mol. Cells 23, 49-56
- Krassowska, A., Gordon-Keylock, S., Samuel, K., Gilchrist, D., Dzierzak, E., Oostendorp, R., Forrester, L.M., and Ansell, J.D. (2006). Promotion of haematopoietic activity in embryonic stem cells by the aorta-gonad-mesonephros microenvironment. Exp. Cell Res. 312, 3595-3603 https://doi.org/10.1016/j.yexcr.2006.08.001
- Krosl, J., Austin, P., Beslu, N., Kroon, E., Humphries, R.K., and Sauvageau, G. (2003). In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat. Med. 9, 1428-1432 https://doi.org/10.1038/nm951
- Kyba, M., Perlingeiro, R.C., and Daley, G.Q. (2002). HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell 109, 29-37 https://doi.org/10.1016/S0092-8674(02)00680-3
- Levenberg, S., Golub, J.S., Amit, M., Itskovitz-Eldor, J., and Langer, R. (2002). Endothelial cells derived from human embryonic stem cells. Proc. Natl. Acad. Sci. USA 99, 4391-4396
- Narayan, A.D., Chase, J.L., Lewis, R.L., Tian, X., Kaufman, D.S., Thomson, J.A., and Zanjani, E.D. (2006). Human embryonic stem cell-derived hematopoietic cells are capable of engrafting primary as well as secondary fetal sheep recipients. Blood 107, 2180-2183 https://doi.org/10.1182/blood-2005-05-1922
- Ng, E.S., Davis, R.P., Azzola, L., Stanley, E.G., and Elefanty, A.G. (2005). Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation. Blood 106, 1601-1603 https://doi.org/10.1182/blood-2005-03-0987
- Pera, M.F., and Trounson, A.O. (2004). Human embryonic stem cells: prospects for development. Development 131, 5515-5525 https://doi.org/10.1242/dev.01451
- Rozemuller, H., Knaan-Shanzer, S., Hagenbeek, A., van Bloois, L., Storm, G., and Martens, A.C. (2004). Enhanced engraftment of human cells in RAG2/gammac double-knockout mice after treatment with CL2MDP liposomes. Exp. Hematol. 32, 1118-1125 https://doi.org/10.1016/j.exphem.2004.08.002
- Sauvageau, G., Thorsteinsdottir, U., Eaves, C.J., Lawrence, H.J., Largman, C., Lansdorp, P.M., and Humphries, R.K. (1995). Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev. 9, 1753-1765 https://doi.org/10.1101/gad.9.14.1753
- Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S., and Jones, J.M. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147 https://doi.org/10.1126/science.282.5391.1145
- Tian, X., Woll, P.S., Morris, J.K., Linehan, J.L., and Kaufman, D.S. (2006). Hematopoietic engraftment of human embryonic stem cell-derived cells is regulated by recipient innate immunity. Stem Cells 24, 1370-1380 https://doi.org/10.1634/stemcells.2005-0340
- Vodyanik, M.A., Bork, J.A., Thomson, J.A., and Slukvin, II (2005). Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential. Blood 105, 617-626 https://doi.org/10.1182/blood-2004-04-1649
- Wang, L., Li, L., Shojaei, F., Levac, K., Cerdan, C., Menendez, P., Martin, T., Rouleau, A., and Bhatia, M. (2004). Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Immunity 21, 31-41 https://doi.org/10.1016/j.immuni.2004.06.006
- Wang, L., Menendez, P., Shojaei, F., Li, L., Mazurier, F., Dick, J.E., Cerdan, C., Levac, K., and Bhatia, M. (2005). Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. J. Exp. Med. 201, 1603-1614 https://doi.org/10.1084/jem.20041888
- Weisel, K.C., Gao, Y., Shieh, J.H., and Moore, M.A. (2006). Stromal cell lines from the aorta-gonado-mesonephros region are potent supporters of murine and human hematopoiesis. Exp. Hematol. 34, 1505-1516 https://doi.org/10.1016/j.exphem.2006.06.013
- Zambidis, E.T., Peault, B., Park, T.S., Bunz, F., and Civin, C.I. (2005). Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development. Blood 106, 860-870 https://doi.org/10.1182/blood-2004-11-4522
- Zhan, X., Dravid, G., Ye, Z., Hammond, H., Shamblott, M., Gearhart, J., and Cheng, L. (2004). Functional antigenpresenting leucocytes derived from human embryonic stem cells in vitro. Lancet 364, 163-171 https://doi.org/10.1016/S0140-6736(04)16629-4