Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
권호 표지
DOI QR코드

DOI QR Code

Inhibitory Effect of Ore Minerals on the Allergic Inflammation in Mouse

  • Park, Seul-Ki (Department of Medical Biotechnology, Soonchunhyang University) ;
  • Lee, Chang-Won (NT&BT Co. Ltd. Research Institute) ;
  • Lee, Mi-Young (Department of Medical Biotechnology, Soonchunhyang University)
  • Published : 2008.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

The ore minerals, mainly composed of sericite, talc, and halloysite, were investigated for their inhibitory effect on the allergic inflammation in mice by measuring the serum IgE level, inflammatory cytokine production, and histamine and ${\beta}$-hexosaminidase releases. When the mice were ovalbumin (OVA)-challenged prior to the ore mineral treatment, the IgE level in the serum decreased significantly. The ore minerals significantly reduced the productions of IL-4 and the tumor necrosis factor-${\alpha}$ in the bronchial alveolar lavage fluid challenged with OVA. The inflammatory infiltrates, found in the lung of the OVA-challenged mouse, were also notably decreased following the ore mineral treatment. The ore minerals significantly reduced the release of histamine and ${\beta}$-hexosaminidase from the RBL-2H3 cells. These results suggest that the ore minerals may be useful as potent inhibitors of the allergic inflammation in mice.

Keywords

References

  1. Averbeck M, Gebhardt C, Emmrich F, Treudler R, and Simon JC (2007) Immunologic principles of allergic disease. J Dtsch Dermatol Ges 5, 1015-1028 https://doi.org/10.1111/j.1610-0387.2007.06538.x
  2. Barsumian EL, Isersky C, Petrino MG, and Siraganian RP (1981) IgE-induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clones. Eur J Immunol 11, 317-323 https://doi.org/10.1002/eji.1830110410
  3. Benhamou M, Ryba NJ, Kihara H, Nishikata H, and Siraganian RP (1993) Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation. J Biol Chem 268, 23318-23324
  4. Bradding P, Feather IH, Wilson S, Bardin PG, Heusser CH, Holgate ST, and Howarth PH (1993) Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5 and IL-6 in human allergic mucosal inflammation. J Immunol 151, 3853-3865
  5. Burd PR, Rogers HW, Gordon JR, Martin CA, Jayaraman S, Wilson SD, Dvorak AM, Galli SJ, and Dorf ME (1989) Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. J Exp Med 170, 245-257 https://doi.org/10.1084/jem.170.1.245
  6. Choi KM, Lee CW, and Lee MY (2008) Effect of ore minerals on the healing of full-thickness skin injury model of rat. J Environ Sci 17, 809-816 https://doi.org/10.5322/JES.2008.17.7.809
  7. Fish SC, Donaldson DD, Goldman SJ, Williams CM, and Kasaian MT (2005) IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13. J Immunol 174, 7716-7724 https://doi.org/10.4049/jimmunol.174.12.7716
  8. Hoffmann A, Jamin A, Foetisch K, May S, Aulepp H, Haustein D, and Vieths S (1999) Determination of the allergenic activity of birch pollen and apple prick test solutions by measurement of $\beta$-hexosaminidase release from RBL-2H3 cells. Comparison with classical methods in allergen standardization. Allergy 54, 446-454 https://doi.org/10.1034/j.1398-9995.1999.00917.x
  9. Jeon YM, Ryu JC, and Lee MY (2007) Proteomic analysis of differentially expressed proteins in human lung cells following formaldehyde treatment. Mol Cell Toxicol 3, 238-245
  10. Jeong HS, Rhim TY, Ahn MH, Yoon PO, Kim SH, Chung IY, Uh ST, Kim SI, and Park CS (2005) Proteomic analysis of differently expressed proteins in a mouse model for allergic asthma. J Korean Med Sci 20, 579-585 https://doi.org/10.3346/jkms.2005.20.4.579
  11. Jonathan P, Paul M, and Paul K (2001) The Biology of Disease (2nd ed.) Blackwell Science, Oxford, UK
  12. Kang DK and Lee MY (2008) Photoprotective effects of minerals from Korean Indigenous Ores on UVA-irradiated human dermal fibroblast. Mol Cell Toxicol 4, 150-156
  13. Kim SC and Byun SH (2005) The effects of oldenlandiae diffusae herba extract on eosinophil, IgE and IL-4 on experimental asthma induced by ovalbumin. Kor J Herbology 20, 35-42
  14. Kim SH, Jun CD, Suk KH, Choi BJ, Lim HJ, Park SJ, Lee SH, Shin HY, Kim DK, and Shin TY (2006) Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. Toxicol Sci 91, 123-131 https://doi.org/10.1093/toxsci/kfj063
  15. Lee JS, Park YM, Park BH, Jung KS, Kim KH, Lee WH, and Park DH (2003) Evaluation of the anti-inflammatory and immunomodulatory effects of BSASM using in vitro experiments. Kor J Pharmacogn 34, 228-232
  16. Lee MR, Han CS, Han DY, Park EJ, Lee SC, and Park HR (2008) Protective effect of neuronal cell on glutamateinduced oxidative stress from viola mandshurica extracts. J Korean Soc Appl Biol Chem 51, 79-83
  17. Metcalfe DD, Kaliner M, and Donlon MA (1981) The mast cell. Crit Rev Immunol 3, 23-74
  18. Metzger H (1992) The receptor with high affinity for IgE. Immunol Rev 125, 37-48 https://doi.org/10.1111/j.1600-065X.1992.tb00624.x
  19. Nakatani K, Atsumi M, Arakawa T, Oosawa K, Shimura S, Nakahata N, and Ohizumi Y (2002) Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant. Biol Pharm Bull 25, 1137-1141 https://doi.org/10.1248/bpb.25.1137
  20. Oh JH, Park HJ, Heo SH, Yang MJ, Yang YS, Song CW, and Yoon SJ (2007) Gene expression analysis of lung injury in rats induced by exposure to MMA-SS welding fume for 30 days. Mol Cell Toxicol 3, 306-313
  21. Park SK, Kim JJ, Jeon YM, and Lee MY (2007) Suppressive effects of Korean indigenous acanthopanax divaritacus on the allergic inflammation. J Appl Biol Chem 50, 155-159
  22. Petersen LJ, Mosbech H, and Skov PS (1996) Allergeninduced histamine release in intact human skin in vivo assessed by skin microdialysis technique: characterization of factors influencing histamine releasability. J Allergy Clin Immunol 97, 672-679 https://doi.org/10.1016/S0091-6749(96)70313-5
  23. Plaut M, Pierce JH, Watson CJ, Hanley-Hyde J, Nordan RP, and Paul WE (1989) Mast cell lines produce lymphokines in response to cross-likage of Fc epsilon RI or to calcium ionophores. Nature 339, 64-67 https://doi.org/10.1038/339064a0
  24. Sy LB, Wu YL, Chiang BL, Wang YH, and Wu WM (2006) Propolis extracts exhibit an immunoregulatory activity in an OVA-sensitized airway inflammatory animal model. Int Immunopharmacol 6, 1053-1060 https://doi.org/10.1016/j.intimp.2006.01.015
  25. White JR, Pluznik DH, Ishizaka K, and Ishizaka T (1985) Antigen-induced increase in protein kinase C activity in plasma membrane of mast cells. Proc Natl Acad Sci USA 82, 8193-8197
  26. Wuthrich B (1989) Epidemiology of the allergic diseases: are they really on the increase? Int Arch Allergy Appl Immunol 90 (Suppl 1), 3-10 https://doi.org/10.1159/000235067
  27. Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, and Caughey GH (2006) Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med 203, 2907-2917 https://doi.org/10.1084/jem.20061232
  28. Yamashita K, Suzuki Y, Matsui T, Yoshimaru T, Yamaki M, Suzuki-Karasaki M, Hayakawa S, and Shimizu K (2000) Epigallocatechin gallate inhibits histamine release from rat basophilic leukemia (RBL-2H3) cells: role of tyrosine phosphorylation pathway. Biochem Biophys Res Commun 274, 603-608 https://doi.org/10.1006/bbrc.2000.3200
  29. Yi JM, Kim MS, Seo SW, Lee KN, Yook CS, and Kim HM (2001) Acanthopanax senticosus root inhibits mast celldependent anaphylaxis. Clin Chim Acta 312, 163-168 https://doi.org/10.1016/S0009-8981(01)00613-1

Cited by

  1. extract by apoptotic pathway in KB human oral cancer cells vol.51, pp.11, 2013, https://doi.org/10.3109/13880209.2013.792847
  2. Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture pp.0260437X, 2013, https://doi.org/10.1002/jat.2858
  3. 광물성 미네랄이 동물세포의 손상에 미치는 효과 vol.18, pp.12, 2008, https://doi.org/10.5322/jes.2009.18.12.1391
  4. Proteomic profiling of the differentially expressed proteins by $TiO_2$ nanoparticles in mouse kidney vol.6, pp.4, 2008, https://doi.org/10.1007/s13273-010-0055-9