대한예방한의학회지 (Journal of Society of Preventive Korean Medicine)
- 제12권2호
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- Pages.37-49
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- 2008
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- 1226-7066(pISSN)
Human Liver Microsome을 이용한 수종 이기약의 간대사효소에 미치는 영향
The Effect to the Hepatic Metabolic Enzume that Uses Human Liver Microsome Caused by a Bariety of Yigiyak
- Kim, Hyun-Ho (Dept. of Preventive Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Shin, Yong-Cheol (Dept. of Preventive Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Ko, Seong-Gyu (Dept. of Preventive Medicine, College of Oriental Medicine, Kyung Hee University)
- 발행 : 2008.08.31
초록
In this study, we experimented the influence of three herbal medicines, which are Saussurea lappa Clarke, Poncirus trifoliata Rafin, Citrus aurantium Linne, which are called 'Yigiyak(理氣藥)' on drug metabolizing enzyme cytochrome P450 3A4 in Human Liver Microsome. Above all, the reason for this study is that herbal medicines can be assumed that herbs might have interactions with drugs, other herbs, alcohol and chemicals whether those are much better synergy effects than expected effects when the medicine was treated alone or not. As a result, we showed that all of five traditional herbal medicines had no CYP 3A4 inhibition effect on 10, 20, 30, 40,