• Journal of Society of Preventive Korean Medicine
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• v.12 no.2
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• pp.37-49
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• 2008

In this study, we experimented the influence of three herbal medicines, which are Saussurea lappa Clarke, Poncirus trifoliata Rafin, Citrus aurantium Linne, which are called 'Yigiyak(理氣藥)' on drug metabolizing enzyme cytochrome P450 3A4 in Human Liver Microsome. Above all, the reason for this study is that herbal medicines can be assumed that herbs might have interactions with drugs, other herbs, alcohol and chemicals whether those are much better synergy effects than expected effects when the medicine was treated alone or not. As a result, we showed that all of five traditional herbal medicines had no CYP 3A4 inhibition effect on 10, 20, 30, 40, $50{\mu}g/m{\ell}$ doses in Human Liver Microsome even Saussurea lappa Clarke showed a little inhibition as about 93% and 79% inhibition rate of control. However, this result are mostly not enough to prove that SLC has a CYP 3A4 inhibition effect. Moreover, it is not that those rates showed that those herbal medicines have CYP 3A4 induction effect. In conclusion, the result could support that those herbal medicines are more safe than chemical drugs even if this is the basic step to prove that result. Therefore, more specific studies to support this result, which are Kinetic study, cell and animal study then finally until clinical research, are required.

• Journal of Haehwa Medicine
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• v.10 no.1
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• pp.375-383
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• 2001

Clinically the arthritis occupies much part of musculoskeletal diseases. The arthrits is subordinate to Bi-jeung in the oriental medicine. The causes of Bi-jeung are almost proposed as Pung-Han-Sup-Yeol, and various herb medication were composed following this standard. In this paper, herb medications corresponded with Bi-jeung of Bangyakhappyeon(方藥合編) were anlysed. And the results are as follws. 1. Herb medications of Bi-jeung were composed with 4 parts, Sangtong(8 medications), Jungtong(7), Hatong(6) and Jeungbobang(7). 2. Herb medications of Bi-jeung were almost composed with Geopungsupyak, Haepyoyak(解表藥), Onryyak(溫裏藥), Boyikyak(補益藥), Yigiyak(理氣藥), and Hwalhyeol-geouhyak. 3. Analysed with a source book, Dongeuibogam was the most quotational literature.