Zolpidem 중독의 임상적 특징에 대한 연구

Clinical Characteristics of Acute Zolpidem Intoxication

  • 서주현 (가천의과학대학교 길병원 내과학교실) ;
  • 노형근 (가천의과학대학교 길병원 내과학교실) ;
  • 어은경 (이화여자대학교 의학전문대학원 응급의학교실) ;
  • 전영진 (이화여자대학교 의학전문대학원 응급의학교실) ;
  • 정구영 (이화여자대학교 의학전문대학원 응급의학교실)
  • Suh, Joo-Hyun (Department of internal Medicine, Gachon University of Medicine and science) ;
  • Roh, Hyung-Keun (Department of internal Medicine, Gachon University of Medicine and science) ;
  • Eo, Eun-Kyung (Department of Emergency Medicine, School of Medicine, Ewha Womans University) ;
  • Cheon, Young-Jin (Department of Emergency Medicine, School of Medicine, Ewha Womans University) ;
  • Jung, Koo-Young (Department of Emergency Medicine, School of Medicine, Ewha Womans University)
  • 발행 : 2008.12.31

초록

Purpose: The hypnotic effect of zolpidem is comparable to benzodiazepines, but has less abuse and addiction potential than benzodiazepines, so is one of the most commonly prescribed hypnotics. The frequency of acute zolpidem overdose has increased, but clinical analysis and severity predictors are not known in Korea. Methods: A retrospective evaluation of histories, clinical courses, and laboratory findings of each patient treated from June, 2000, to May, 2006, in a university hospital for acute zolpidem intoxication. Results: We evaluated 30 patients, including 16 co-intoxication cases. Twenty-five patients presented mental alterations but became alert within 2 days. All patients recovered completely. The median zolpidem concentration was 0.9 mg/L (range: $0.2{\sim}7.4\;mg/L$). There was a weak correlation between the amount ingested and zolpidem concentration (r=0.25). None of them presented severe laboratory abnormalities, and these abnormalities did not relate to zolpidem concentration. Conclusion: The clinical progress of acute zolpidem intoxication is mild. We could not predict zolpidem concentration or clinical severity from the amount ingested and could not predict the clinical course from laboratory findings in the emergency department.

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