급성 유기인계 농약 중독

Acute Organophosphorus Pesticide Poisoning

  • 이미진 (건양대학교 의과대학 응급의학교실) ;
  • 박준석 (건양대학교 의과대학 응급의학교실) ;
  • 홍태용 (카톨릭대학교 의과대학 응급의학교실) ;
  • 박성수 (건양대학교 의과대학 응급의학교실) ;
  • 유연호 (건양대학교 의과대학 응급의학교실)
  • Lee, Mi-Jin (Department of Emergency Medicine, College of Medicine, Konyang University) ;
  • Park, Joon-Seok (Department of Emergency Medicine, College of Medicine, Konyang University) ;
  • Hong, Tai-Yong (Department of Emergency Medicine, College of Medicine, The Catholic University of Korea) ;
  • Park, Sung-Soo (Department of Emergency Medicine, College of Medicine, Konyang University) ;
  • You, Yeon-Ho (Department of Emergency Medicine, College of Medicine, Konyang University)
  • 발행 : 2008.12.31

초록

Organophosphate (OP) pesticides are the most common source of human toxicity globally, causing high mortality and morbidity despite the availability of atropine as a specific antidote and oximes to reactivate acetylcholinesterase. The primary toxicity mechanism is inhibition of acetylcholinesterase (AchE), resulting in accumulation of the neurotransmitter, acetylcholine, and abnormal stimulation of acetylcholine receptors. Thus, the symptoms (muscarinic, nicotinic, and central nervous system) result from cholinergic overactivity because of AchE inhibition. OP can also cause rhabdomyolysis, pancreatitis, parotitis, and hepatitis. OP therapy includes decontamination, supportive therapy, and the use of specific antidotes such as atropine and oximes. However, there has been a paucity of controlled trials in humans. Here we evaluated the literature for advances in therapeutic strategies for acute OP poisoning over the last 10 years.

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