청정기술 (Clean Technology)
- 제14권4호
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- Pages.242-247
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- 2008
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- 1598-9712(pISSN)
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- 2288-0690(eISSN)
초임계 반용매법을 이용한 폴리비닐피롤리돈 미세입자의 제조
Preparation of Poly(N-vinyl-2-pyrrolidone) Microparticles Using Supercritical Anti-solvent
- Shin, Moon-Sam (School of Chemical and Biological Engineering, Seoul National University) ;
- Kim, Hwa-Yong (School of Chemical and Biological Engineering, Seoul National University)
- 발행 : 2008.12.31
초록
화장품, 의약품, 전자소재 분야에서 생체적합, 생분해성 고분자로 널리 사용되는 폴리비닐피롤리돈(PVP)을 에어로젤 용매추출 방법에 의해 미세입자를 제조하였다. 용매로는 이 염화메탄올, 반용매로는 초임계 이산화탄소가 사용되었다. 온도, 압력, 이산화탄소 유량, 용액유량의 작업조건에 따라 0.184 -
Poly(N-vinyl-2-pyrrolidone) (PVP) has been used as biocompatible and biodegradable polymer in cosmetics, pharmaceuticals and electronics. Micro-particles of PVP were produced using an aerosol solvent extraction system (ASES). Dichloromethane (DCM) and supercritical carbon dioxide were used as solvent and antisolvent, respectively. The mean diameter of the obtained polymer particles ranged from 0.184 to
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