The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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The Effect of Caffeic Acid on Wound Healing in Skin-incised Mice

  • Song, Ho-Sun (Department of Pathophysiology, College of Medicine, Chung-Ang University) ;
  • Park, Tae-Wook (Department of Pathophysiology, College of Medicine, Chung-Ang University) ;
  • Sohn, Uy-Dong (Department of Pharmacology, College of Pharmacy, College of Medicine, Chung-Ang University) ;
  • Shin, Yong-Kyoo (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
  • Choi, Byung-Chul (Department of Pathophysiology, College of Medicine, Chung-Ang University) ;
  • Kim, Chang-Jong (Department of Pathophysiology, College of Medicine, Chung-Ang University) ;
  • Sim, Sang-Soo (Department of Pathophysiology, College of Medicine, Chung-Ang University)
  • Published : 2008.12.31
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Abstract

This study was carried out to investigate the wound healing effect of caffeic acid in skin-incised mice. Caffeic acid showed significant effects on anti-inflammatory activity and wound healing, such as myeloperoxidase activity, lipid peroxidation, phospholipase $A_2$ activity and collagen-like polymer synthesis, in incised-wound tissue. On the other hand, it significantly stimulated collagen-like polymer synthesis in NIH 3T3 fibroblast cells, while inhibited both silica-induced reactive oxygen species generation and melittin-induced arachidonic acid release and $PGE_2$ production in Raw 264.7 cells, and histamine release in RBL 2H3 cells stimulated by melittin or arachidonic acid. Therefore, caffeic acid appears to have a potent antioxidant and anti-inflammatory effect in cell culture system, which may be related to wound healing in skin-incised mice.

Keywords

References

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