한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제25권6호
  • /
  • Pages.488-493
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  • 2008
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

Effects of Injectable Anesthetics on Fluorescein Retinal Angiographic Phases in Dogs

  • Jang, Jae-Young (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Young-Sam (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Won-Tae (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Jung, Chang-Su (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Hyun-Ah (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Min-Su (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Yi, Na-Young (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Jeong, Man-Bok (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Nam, Tchi-Chou (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Seo, Kang-Moon (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
  • 발행 : 2008.12.31
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초록

This study compared the effect of injectable combinations of anesthetics on each of the fluorescein angiographic phases in order to determine the most useful anesthetic combination for the procedure. Acepromazineketamine (AK), xylazine-ketamine (XK), diazepam-ketamine (DK) and zolazepam-tiletamine (ZT) group were administered randomly to 8 dogs with a two-week interval between different combination doses. The vital signs including the heart rate and arterial pressure were measured before anesthesia and every five minutes during anesthesia. Serial angiographic images were obtained after injecting a sodium fluorescein dye (25 mg/kg) and the onset time of arterial phase (AP), arteriovenous phase (AVP), early venous phase (EVP) and late venous phases (LVP) were recorded. The onset time of the AP, AVP and EVP were significantly slower in the AK and XK groups than in the DK and ZT groups. The total duration of the AP and AVP in the AK group was significantly longer than those in the ZT group. The heart rates were significantly higher in the DK and ZT groups. The arterial pressure was significantly higher in the AK and XK groups (p<0.05). There were significant differences in each angiographic onset time and duration depending on the changes in the heart rates and arterial pressure. The AK and XK groups showed a long angiographic duration allowing an accurate evaluation. Overall, it is believed that AK and XK are more useful for performing fluorescein retinal angiography than DK and ZT.

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참고문헌

  1. Barnett KC, Samson J, Heinrich C. Examination of the eye and adnexa. In: Canine ophthalmology, 1st ed. (Barnett, K. C. ed.), B. W. Saunders, London. 2002: 1-8
  2. Finieschi V, Monasterolo G, Rosi R, Turillazzi E. Fatal anaphylactic shock during a fluorescein angiography. Forensic Science International 1999; 100: 137-142 https://doi.org/10.1016/S0379-0738(98)00205-9
  3. Foreest AW. The application of tiletamine/zolazepam (Zoletil) anesthesia in dental treatments in dogs. Tijdschr Diergeneeskd 1991; 116: 1063-1066
  4. Gelatt KN, Henderson JD, Steffen GR. Fluorescein angiography of the normal and diseased ocular fundi of the laboratory dog. J Am Vet Med Assoc 1976; 169: 980-984
  5. Haskins SC, Farver TB, Patz JD. Cardiopulmonary effects of acepromazine and of the subsequent administration of ketamine in the dog. Am J Vet Res 1986; 47: 631-635
  6. Haskins SC, Farver TB, Patz JD. Xylazine and xylazineketamine in dogs. Am J Vet Res 1986; 47: 636-641
  7. Haskins, SC, Farver, TB, Patz, JD. Cardiovascular changes in dogs given diazepam and diazepam-ketamine. Am J Vet Res 1986; 47: 795-798
  8. Helly P, Muir WW, Hubbell JA, Sally J. Cardiorespiratory effects of the intravenous administration of tiletamine-zolazepam to dogs. Vet Surg 1989; 18: 160-165 https://doi.org/10.1111/j.1532-950X.1989.tb01063.x
  9. Hogan MJ, Eckelhoff RJ. Fluorescein angiography of the ocular fundus. Am Fam Physician 1972; 5: 101-106
  10. Johnson RN, McDonald HR, Schatz H. Rash, fever, and chills after intravenous fluorescein angiography. Am J Ophthalmol 1998; 126: 837-838 https://doi.org/10.1016/S0002-9394(98)00202-5
  11. Kommonen B, Koskinen L. Fluorescein angiography of the canine ocular fundus in ketamine-xylazine anesthesia. Acta Vet Scand 1984; 25: 346-351
  12. Lin HC. Dissociative Anesthetics. In: Veterinary Anesthesia , 3rd ed. (Thurmon, J.C., Tranquilli, W.J. and Benson, G.J. eds.), Williams & Wilkins, Maryland. 1996: 241-287
  13. Martin E, Redondo JI, Molleda JM, Santisteban JM, Lopez R, Gomez-Villamandos R. Effects of sevoflurane, isoflurane and halothane anaesthesia on fluorescein angiographic phases of dogs: a comparative study. J Vet Med A Physiol Pathol Clin Med 2001; 48: 267-75 https://doi.org/10.1046/j.1439-0442.2001.00341.x
  14. Potoczak R, Corey R. The effects of CI-744 upon cardiovascular function in the dog. Fed Proc 1975; 34: 771
  15. Plumb DC. Ketamine. In: Veterinary drug handbook, 4th ed. (Plumb, D.C. ed.), Iowa state press, Iowa. 2001: 483
  16. Schaepdrijver L, Simoens P, Lauwers H. Fluorescein angiography of the canine retina. Vet Comp Ophthalmol 1996; 6: 111-119
  17. Schaepdrijver L, Simoens P, Pollet L, Lauwers H, de Laey JJ. Morphorogic and clinical study of the retinal circulation in the miniature pig, B: Fluorescein anigiography of the retina. Exp Eye Res 1992; 54: 975-985 https://doi.org/10.1016/0014-4835(92)90162-L
  18. Strubbe DT, Gelatt KN. Ophthalmic examination and diagnostic procedures. In: Veterinary ophthalmology, 3rd ed. (Gelatt, K.N. ed.), Lippincott Willams & Wilkins, Pennsylvania. 1999: 444-446
  19. Walde I. Das Fluoreszenzangigramm des Normalen Augenhintergrundes bei Hund und Pferd. Tierarztl Prax 1977; 5: 343-347
  20. Wilcock B. Basic diagnostic techniques. In: Fundamentals of veterinary ophthalmology, 3rd ed. (Slatter, D. ed.), B. W. Saunders, Philadelphia. 2001: 114-115
  21. Wright, M. Pharmacologic effects of ketamine and its use in veterinary medicine. J Am Vet Med Assoc 1982; 180: 1462-1471