Journal of the Korean Academy of Child and Adolescent Psychiatry
- 제19권3호
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- Pages.147-155
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- 2008
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- 2233-9183(eISSN)
주의력결핍 과잉행동장애 아동에서 공존질환에 따른 OROS-Methylphenidate의 효과와 안전성
Efficacy and Tolerability of Osmotic Release Oral System-Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder According to Comorbid Psychiatric Disorders
- 윤형준 (한림대학교 의과대학 정신과학교실) ;
- 육기환 (포천중문의과대학 분당차병원 정신과학교실) ;
- 전덕인 (한림대학교 의과대학 정신과학교실) ;
- 석정호 (한림대학교 의과대학 정신과학교실) ;
- 홍나래 (한림대학교 의과대학 정신과학교실) ;
- 조성식 (한림대학교 의과대학 산업의학교실) ;
- 홍현주 (한림대학교 의과대학 정신과학교실)
- Yoon, Hyung-Jun (Department of Psychiatry, Hallym University College of Medicine) ;
- Yook, Ki-Hwan (Department of Psychiatry, Pochon CHA University College of Medicine) ;
- Jon, Duk-In (Department of Psychiatry, Hallym University College of Medicine) ;
- Seok, Jeong-Ho (Department of Psychiatry, Hallym University College of Medicine) ;
- Hong, Na-Rei (Department of Psychiatry, Hallym University College of Medicine) ;
- Cho, Sung-Shick (Department of Occupational and Environmental Medicine, Hallym University College of Medicine) ;
- Hong, Hyun-Ju (Department of Psychiatry, Hallym University College of Medicine)
- 발행 : 2008.10.30
초록
Objectives: The purpose of this study was to evaluate the efficacy and tolerability of osmotic release oral system-methylphenidate (OROS-MPH) in children with attention-deficit hyperactivity disorder (ADHD) and comorbid psychiatric disorders. Methods: This was an 8-week open label study of OROS-MPH monotherapy. The subjects were 113 children with ADHD aged 6-12 years. Outcome measures were the Korean version of the parent ADHD Rating Scale (K-ARS), Korean version of the Conners Parent Rating Scale (K-CPRS), Clinical Global Impression-Severity and Clinical Global Impression-Improvement. Side effects were monitored using Barkley's Side Effect Rating Scale. We compared the change-over-time in the mean scores of the outcome measure according to the comorbidity of disruptive behavior disorder, depressive disorder, anxiety disorder, and tic disorder. Results: The mean K-ARS and K-CPRS scores were significantly decreased, regardless of the comorbidity. The mean doses of OROS-MPH and dropout rate did not differ significantly according to comorbidity. The OROS-MPH was well tolerated, regardless of the comorbidity. However, children with tic disorder reported a higher frequency of tics or nervous movements between the
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