Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
권호 표지
DOI QR코드

DOI QR Code

Characterization of Dexamethasone-eluting PLGA Films Coated on Capsular Tension Ring to Prevent Posterior Capsule Opacification

  • Chang, Byung-Kon (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Kim, Bo-Gyun (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Kim, Young-Jae (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Kang, Myung-Joo (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Lee, Jae-Hwi (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Choi, Young-Wook (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University)
  • Published : 2008.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

The objectives of this study were to prepare PLGA film onto the surface of the capsular tension ring (CTR) for controlled drug release and investigate the influence of plasticizers, the test drug and measurement conditions on flexibility of the film. Film solutions were prepared by dissolving PLGA, plasticizer (triethyl citrate, TEC or polyethylene glycol, PEG), test drug (dexamethasone) in ethyl acetate then films were prepared by spray coating and evaporation method. Then, the flexibility of PLGA film was determined by elongation test. The addition of plasticizer, PEG or TEC to PLGA copolymer caused a depression of glass transition temperature ($T_g$) and the elasticity of PLGA films increased. The addition of dexamethasone to the PLGA/TEC matrix decreased the flexibility of film. Dimensional factors of the PLGA films such as width and thickness were significantly influenced on flexibility of films and film length and elongation speed had no considerable influence on elongation of films. In this study, sufficiently flexible and stable PLGA films capable of being coated onto CTR could be prepared. This PLGA films can be used as a platform for local drug delivery.

Keywords

References

  1. Apple, D. J., Peng, Q., Visessook, N., Werner, L., Pandey, S. K., Escobar, Gomez, M., Ram, J., Whiteside, S. B., Schoderbeck, R., Ready, E. L. and Guindi, A. (2000). Surgical prevention of posterior capsule opacification. Part 1: Progress in eliminating this complication of cataract surgery. J. Cataract Refract. Surg. 26, 180-187 https://doi.org/10.1016/S0886-3350(99)00353-3
  2. Bertelmann, E. and Kojetinsky, C. (2001). Posterior capsule opacification and anterior capsule opacification. Curr. Opin. Ophthalmol. 12, 35-40 https://doi.org/10.1097/00055735-200102000-00007
  3. Brodbeck, K. J., Pushpala, S. and Mchugh, A. J. (1999). Sustained release of human growth hormone from PLGA solution depots. Pharm. Res. 16, 1825-1829 https://doi.org/10.1023/A:1018943107688
  4. Dorta, M. J., Oliva, A., Munguia, O., Llabres, M. and Farina, J. B. (2002). In-vitro release of fluoropyrimidines from PLGA film implants. J. Pharm. Pharmacol. 54, 757-763 https://doi.org/10.1211/0022357021779096
  5. Fernandez, V., Fragoso, M. A., Billotte, C., Lamar, P., Orozco, M. A., Dubovy, S., Willcox, M. and Parel, J. M. (2004). Efficacy of various drugs in the prevention of posterior capsule opacification: experimental study of rabbit eyes. J. Cataract Refract. Surg. 30, 2598-2605 https://doi.org/10.1016/j.jcrs.2004.05.013
  6. Ferruti, P., Penco, M., D'addato, P., Ranucci, E. and Deghenghi, R. (1995). Synthesis and properties of novel block copolymers containing poly(lactic-glycolic acid) and poly(ethyleneglycol) segments. Biomaterials 16, 1423-1428 https://doi.org/10.1016/0142-9612(95)96879-5
  7. Gumusderelioglu, M. and Deniz, G. (2000). Sustained release of mitomycin-C from poly(DL-lactide) /poly(DL-lactide-co-glycolide) films. J. Biomater. Sci. Polym. Ed. 11, 1039-1150 https://doi.org/10.1163/156856200743562
  8. Ismail, M. M., Alio, J. L. and Ruiz Moreno, J. M. (1996). Prevention of secondary cataract by antimitotic drugs: experimental study. Ophthalmic Res. 28, 64-69
  9. Kranz, H., Ubrich, N., Maincent, P. and Bodmeier, R. (2000). Physicomechanical properties of biodegradable poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) films in the dry and wet states. J. Pharm. Sci. 89, 1558-1566 https://doi.org/10.1002/1520-6017(200012)89:12<1558::AID-JPS6>3.0.CO;2-8
  10. Legler, U. F., Apple, D. J., Assia, E. I., Bluestein, E. C., Castaneda, V. E. and Mowbray, S. L. (1993). Inhibition of posterior capsule opacification: the effect of colchicines in a sustained drug delivery system. J. Cataract Refract. Surg. 19, 462-470 https://doi.org/10.1016/S0886-3350(13)80609-8
  11. Painter, P. C. and Coleman, M. M. (1997). Fundamentals of polymer science, an introductory text. 2 ed. CRC press., New York
  12. Pandey, S. K., Cochener, B., Apple, D. J., Colin, J., Werner, L., Bougaran, R., Trivedi, R. H., Macky, T. A. and Izak, A. M. (2002). Intracapsular ring sustained 5-fluorouracil delivery system for the prevention of posterior capsule opacification in rabbits: a histological study. J. Cataract Refract. Surg. 28, 139-148 https://doi.org/10.1016/S0886-3350(01)01069-0
  13. Peng, Q., Apple, D. J., Visessook, N., Werner, L., Pandey, S. K., Escobar-Gomez, M., Schoderbek, R. and Guindi, A. (2000). Surgical prevention of posterior capsule opacification. Part 2: Enhancement of cortical cleanup by focusing on hydrodissection. J. Cataract Refract. Surg. 26, 188-197 https://doi.org/10.1016/S0886-3350(99)00354-5
  14. Peng, Q., Visessook, N., Apple, D. J., Pandey, S. K., Werner, L., Escobar-Gomez, M., Schoderbek, R., Solomon, K. D. and Guindi, A. (2000). Surgical prevention of posterior capsule opacification. Part 3: Intraocular lens optic barrier effect as a second line of defense. J. Cataract. Refract. Surg. 26, 198-213 https://doi.org/10.1016/S0886-3350(99)00352-1
  15. Power, W. J., Neylan, D. and Collum, L. M. (1994). Daunomycin as an inhibitor of human lens epithelial cell proliferation in culture. J. Cataract. Refract. Surg. 20, 287-290 https://doi.org/10.1016/S0886-3350(13)80579-2
  16. Ruiz, J. M., Medrano, M. and Alio, J. L. (1990). Inhibition of posterior capsule opacification by 5-fluorouracil in rabbits. Ophthalmic Res. 22, 201-208 https://doi.org/10.1159/000267024
  17. Tetz, M. R., Ries, M. W., Lucas, C., Stricker, H. and Volcker, H. E. (1996). Inhibition of posterior capsule opacification by an intraocular-lens-bound sustained drug delivery system: an experimental animal study and literature review. J. Cataract. Refract. Surg. 22. 1070-1078 https://doi.org/10.1016/S0886-3350(96)80120-9
  18. Webber, W. L., Lago, F., Thanos, C. and Mathiowitz, E. (1998). Characterization of soluble, salt-loaded, degradable PLGA films and their release of tetracycline. J. Biomed. Mater. Res. 41, 18-29 https://doi.org/10.1002/(SICI)1097-4636(199807)41:1<18::AID-JBM3>3.0.CO;2-T