Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Suppressive Effect of a Carbohydrate Fraction from Eclipta prostrata on the Apoptosis of the Mouse Splenocytes in Culture

  • Bae, Eun-Kyong (School of Biological Sciences and Bio-health Products Research Center, Inje University) ;
  • Kim, Na-Ri (School of Biological Sciences and Bio-health Products Research Center, Inje University) ;
  • Yun, Mi-Jung (School of Biological Sciences and Bio-health Products Research Center, Inje University) ;
  • Youn, Hyong-Chol (School of Biological Sciences, Seoul National University) ;
  • Youn, Kyung-Joon (School of Biological Sciences, Seoul National University) ;
  • Lee, Kang-Ro (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University) ;
  • Youn, Hyun-Joo (School of Biological Sciences and Bio-health Products Research Center, Inje University)
  • Published : 2008.12.31
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Abstract

Eclipta prostrata grows abundantly in the tropical and the sub-tropical parts of the world including most part of the Korean Peninsula. The plant has been traditionally used for the treatment of a number of inflammatory diseases including hepatitis and enteritis but the nature of its immuno-modulating activity needs more studies. In this study, water-soluble sugar-containing fractions were purified from the herb and their effects on the culture of mouse splenocytes were examined. One of the fractions significantly suppressed apoptosis of the splenocytes in culture, which involves the gene expression regulation of a number of cytokines and cytokine receptors including MIP1-$\beta$. This study could explain an immunological activity of Eclipta prostrata and would lead to identify an immuno-active compound from the plant.

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References

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