Bulletin of the Korean Chemical Society

  • 제29권8호
  • /
  • Pages.1533-1538
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  • 2008
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Direct Stacking of Non-metallic Planar Porphyrin to DNA

  • Lee, Min-Ju (Department of Chemistry, Yeungnam University) ;
  • Jin, Biao (Department of Chemistry, Yeungnam University) ;
  • Lee, Hyun-Mee (Department of Chemistry, Yeungnam University) ;
  • Jung, Maeng-Joon (School of Applied Chemical Engineering, Kyungpook National University) ;
  • Kim, Seog K. (Department of Chemistry, Yeungnam University) ;
  • Kim, Jong-Moon (Department of Chemistry, Yeungnam University)
  • 발행 : 2008.08.20
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초록

Porphyrins generally bind DNA in two different ways with respect to the mixing ratio; monomeric binding at a low mixing ratio and outside stacking at a high mixing ratio. In the present study, CTDNA binding property of a planar structured porphyrin, 5,10,15,20-tetrakis(N-methyl-4-pyridin-4-yl-phenyl)porphyrin (referred to as B-TMPyP) was investigated using absorption, CD, LD, and $LD^r$ spectroscopies. B-TMPyP produced a bisignate CD band, even at the lowest mixing ratio, indicating that B-TMPyP may not have a monomeric binding mode. From the observations of the spectral changes to the absorption, CD, and LD spectra in mixing ratio dependent titrations, B-TMPyP seems to have a quite different stacking type compared to that for the binding of $H_2$TMPyP. Moreover, B-TMPyP produced a CD band of opposite shape in the Soret band region. A qualitative explanation for the observed optical differences is also given.

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