Bulletin of the Korean Chemical Society

  • 제29권10호
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  • Pages.1946-1950
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  • 2008
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Biological Properties of New 5-Cyano-1,1-disubstituted Phthalans for the Treatment of Premature Ejaculation

  • 발행 : 2008.10.20
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초록

The synthesis of new 5-cyano-1,1-disubstituted phthalans having aromatic and aminoalkyl groups at C-1 position of phthalan ring and their biological evaluation are described. Most compounds exhibited comparable ejaculation-retarding effects to citalopram. Of these compounds, 3a, e showed excellent efficacy in delaying ejaculation.

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피인용 문헌

  1. Phthalides and Phthalans: Synthetic Methodologies and Their Applications in the Total Synthesis vol.114, pp.12, 2014, https://doi.org/10.1021/cr400524q
  2. Potentiality and Synthesis of O- and N-Heterocycles: Pd-Catalyzed Cyclocarbonylative Sonogashira Coupling as a Valuable Route to Phthalans, Isochromans, and Isoindolines pp.1434193X, 2017, https://doi.org/10.1002/ejoc.201701041
  3. ChemInform Abstract: Synthesis and Biological Properties of New 5-Cyano-1,1-disubstituted Phthalans for the Treatment of Premature Ejaculation. vol.40, pp.9, 2009, https://doi.org/10.1002/chin.200909103