Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Approaches to the Syntheses of Partially Reduced Imidazo[1,2-a]pyridines

  • Shin, Jun-Hwa (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Nho, Young-Chang (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Howard, Arthur S. (Department of Chemistry, Eastern Michigan University)
  • Published : 2008.10.20
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Abstract

Two synthetic pathways to substituted hexahydroimidazo[1,2-a]pyridines, which may serve as precursors of aza-alkaloids, were investigated. The first involves the condensation of a bisnucleophilic enediaminoester and a biselectrophile. The second involves attachment to nitrogen of the carbon chain skeleton required to form the six-memberd ring, before formation of the enediaminoester. Several substituted hexahydroimidazo[1,2- a]pyridines were synthesized via these two approaches.

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References

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